Compare Aygestin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aygestin (norethindrone)

Prescription only

Prometrium (Progesterone)

Prescription only
Regulates your menstrual cycle and treats irregular bleeding.

Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.

3.6/ 7 average rating with 30 reviewsforAygestin
Taken for irregular bleeding or paired with estrogen replacements for menopause.

Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.

4.6/ 7 average rating with 64 reviewsforPrometrium
Upsides
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Used for
  • Pain caused by endometriosis
  • Balances hormones in women who don't have regular monthly periods
  • Balances hormones in women who have unusual monthly periods
  • Amenorrhea
  • Prevention of uterine cancer in women taking estrogen
  • Abnormal uterine bleeding
Dosage forms
  • Pill
  • Pill
  • Injection
Price
Lowest price near you
$9
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Lowest price near you
$23.76
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Reviews
30 
40%
think this treatment is worth it
23%
think this treatment works well
23%
think this treatment is a hassle

Have you used Aygestin (norethindrone)?

Leave a review
64 
61%
think this treatment is worth it
41%
think this treatment works well
17%
think this treatment is a hassle

Have you used Prometrium (Progesterone)?

Leave a review
Side effects
The Aygestin (norethindrone) FDA package insert doesn’t have numbers about how common side effects are.
The Prometrium (Progesterone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Depression

    History of depression

  • Changes in blood sugar levels

    Diabetes

  • Liver problems

    History of liver problems

  • High cholesterol levels

    High cholesterol levels

See more detailed risks and warnings
  • Breast cancer

    Personal or family history of breast cancer

  • Ovarian cancer

    Family history of ovarian cancer

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 6 more risk factors

  • Severe allergic reactions

    Allergy to peanuts

  • Fluid retention (Foot and leg swelling)

    Heart failure

    ...and 2 more risk factors

  • Depression

    History of depression

See more detailed risks and warnings