Compare Aygestin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aygestin
(Norethindrone)

Prometrium
(Progesterone)

Regulates your menstrual cycle and treats irregular bleeding. Aygestin (Norethindrone) regulates the menstrual cycle and treats heavy vaginal bleeding. It's easy to take and isn't expensive.Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.6Aygestin
Reviews for Aygestin (Norethindrone)
40%
of people say Aygestin (Norethindrone) is worth it
23%
say it works well
23%
say it's a big hassle
Reviews for Prometrium (Progesterone)
62%
+22% vs. Aygestin (Norethindrone)
41%
+18% vs. Aygestin (Norethindrone)
16%
+7% vs. Aygestin (Norethindrone)
Side effects
AygestinPrometrium

We haven’t found good data for Aygestin side effects.

FDA side effect reports for Aygestin »
  • Breast tenderness 21%
  • Dizziness 20%
  • Breast pain 8%
  • Musculoskeletal pain 8%
  • Low mood disorder 7%
  • Abdominal pain (cramping) 7%
  • Vaginal discharge 7%
  • Abdominal bloating 7%
  • Worry 4%
  • Irritability 4%
More Prometrium side effects »
How it works
AygestinPrometrium
Aygestin (Norethindrone) contains norethindrone, a progestin, which is a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.
Type of medication
AygestinPrometrium
ProgestinPrescription only
ProgestinPrescription only
Available as
AygestinPrometrium
  • Pill
  • Pill
  • Injection
Used for (click to learn more)
AygestinPrometrium
  • Amenorrhea
  • Amenorrhea
Risk factors for serious side effects
AygestinPrometrium
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • History of depression
  • Diabetes
  • History of liver problems
  • High cholesterol levels
  • Women of childbearing age
Detailed Aygestin (Norethindrone) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Allergy to peanuts
  • Heart failure
  • Kidney problems
  • Obesity
  • History of depression
Detailed Prometrium (Progesterone) risks & warnings »
Pregnancy category
AygestinPrometrium
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Weight
  • Can make you gain weight.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Upsides and benefits
AygestinPrometrium
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Aygestin (Norethindrone) is available as a generic medication, so it costs less.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides and risks
AygestinPrometrium
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Tips from our pharmacists for people taking the medication
AygestinPrometrium
  • The dose of Aygestin (Norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (Norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (Norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (Norethindrone).
  • It's important to take it the same time every day.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • It's important to take it the same time every day.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
Learn more
More about AygestinSide effectsReviews & ratingsAlternativesFDA package insert
More about PrometriumSide effectsReviews & ratingsAlternativesFDA package insert