Compare Aygestin vs. Provera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aygestin
(Norethindrone)

Provera
(Medroxyprogesterone)

Regulates your menstrual cycle and treats irregular bleeding. Aygestin (Norethindrone) regulates the menstrual cycle and treats heavy vaginal bleeding. It's easy to take and isn't expensive.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.6Aygestin
Reviews for Aygestin (Norethindrone)
40%
of people say Aygestin (Norethindrone) is worth it
23%
say it works well
23%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
AygestinProvera

We haven’t found good data for Aygestin side effects.

FDA side effect reports for Aygestin »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
AygestinProvera
Aygestin (Norethindrone) contains norethindrone, a progestin, which is a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
AygestinProvera
ProgestinPrescription only
Hormone replacement
Progestin
Prescription only
Available as
AygestinProvera
  • Pill
  • Pill
Used for (click to learn more)
AygestinProvera
  • Amenorrhea
  • Amenorrhea
Risk factors for serious side effects
AygestinProvera
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • History of depression
  • Diabetes
  • History of liver problems
  • High cholesterol levels
  • Women of childbearing age
Detailed Aygestin (Norethindrone) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • History of depression
  • History of liver problems
  • Women of childbearing age
Detailed Provera (Medroxyprogesterone) risks & warnings »
Pregnancy category
AygestinProvera
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
No specific sleep-related info.
Weight
  • Can make you gain weight.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
Upsides and benefits
AygestinProvera
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Aygestin (Norethindrone) is available as a generic medication, so it costs less.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
Downsides and risks
AygestinProvera
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
Tips from our pharmacists for people taking the medication
AygestinProvera
  • The dose of Aygestin (Norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (Norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (Norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (Norethindrone).
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
Learn more
More about AygestinSide effectsReviews & ratingsAlternativesFDA package insert
More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert