Compare Azilect vs. carbidopa / levodopa extended release

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azilect
(rasagiline)

Sinemet CR
(carbidopa / levodopa extended release)

Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.Treats Parkinson's disease. Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.
Reviews & ratings
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Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it

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Have you used Sinemet CR (carbidopa / levodopa extended release)?
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Side effects
Azilectcarbidopa / levodopa extended release
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
  • Difficulty controlling movements 17%
  • Nausea 6%
  • Hallucinations 4%
  • Confusion 4%
  • Dizziness 3%
  • Depression 2%
  • Urinary tract infection 2%
  • Back pain 2%
  • Unusual dreams 2%
  • Muscle spasms 2%
More carbidopa / levodopa extended release side effects »
How it works
Azilectcarbidopa / levodopa extended release
Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.Sinemet CR (carbidopa / levodopa extended release) is a combination of carbidopa and levodopa that is released in your body over time. Carbidopa prevents breakdown of levodopa so that levodopa can then, enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
Azilectcarbidopa / levodopa extended release
Prescription onlyPrescription only
Available as
Azilectcarbidopa / levodopa extended release
  • Pill
  • Extended release
Used for
Azilectcarbidopa / levodopa extended release
Risk factors for serious side effects
Azilectcarbidopa / levodopa extended release
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
  • Taking other medicines for Parkinson's
  • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet CR (carbidopa / levodopa extended release) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
Azilectcarbidopa / levodopa extended release
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
  • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
Downsides and risks
Azilectcarbidopa / levodopa extended release
  • It can cause unusual cravings and changes in behavior in some people.
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
Tips from our pharmacists for people taking the medication
Azilectcarbidopa / levodopa extended release
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Take Sinemet CR (carbidopa / levodopa extended release) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
Learn more
More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
More about carbidopa / levodopa extended releaseSide effectsAlternativesFDA package insert
Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it