Compare Azilect vs. Duopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azilect
(rasagiline)

Duopa
(carbidopa / levodopa)

Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.Treats advanced stages of Parkinson's disease. Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.
Reviews & ratings
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Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it

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Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
AzilectDuopa
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
  • Problems with j-tube 56%
  • Nausea 30%
  • Constipation 22%
  • Redness and swelling at the j-tube site 19%
  • Difficulty controlling movements 14%
  • Low mood disorder 11%
  • Discharge at the j-tube site 11%
  • Swelling in the arms and legs 8%
  • High blood pressure 8%
  • Flu and cold 8%
More Duopa side effects »
How it works
AzilectDuopa
Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.Duopa (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
AzilectDuopa
Prescription onlyPrescription only
Available as
AzilectDuopa
  • Pill
  • Liquid
Used for
AzilectDuopa
Risk factors for serious side effects
AzilectDuopa
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
  • Surgery to place the J-tube
  • Taking other medicines for Parkinson's
  • Stopping Duopa (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Duopa (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Pain
AzilectDuopa
No pain related info.
  • Call your doctor right away if you start having stomach pains around where the pump is connected.
Sleep
AzilectDuopa
No sleep related info.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Duopa (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
Upsides and benefits
AzilectDuopa
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
  • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
Downsides and risks
AzilectDuopa
  • It can cause unusual cravings and changes in behavior in some people.
  • Given via pump so you'll need to have a procedure to attach the pump to your body.
  • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
  • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
  • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
Tips from our pharmacists for people taking the medication
AzilectDuopa
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
  • Duopa (carbidopa / levodopa) is given via pump. You need to have a minor procedure to connect the pump to your body.
  • You may still need to take carbidopa/levodopa in tablet form at night or if the pump disconnects.
  • Call your doctor right away if you start having stomach pains around where the pump is connected.
  • Duopa (carbidopa / levodopa) is only good for 16 hours. Throw out the cassette when the infusion is done even if there's still medicine left inside.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Duopa (carbidopa / levodopa) suddenly. It can be very dangerous. Talk to your doctor if you want to stop taking Duopa (carbidopa / levodopa).
Learn more
More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
More about DuopaSide effectsAlternativesFDA package insert
Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it