Compare Azilect vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azilect
(rasagiline)

Mirapex
(pramipexole)

Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.
Reviews & ratings
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Have you used Azilect (rasagiline)?
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Have you used Mirapex (pramipexole)?
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Side effects
AzilectMirapex
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
  • Any side effect 1%
  • Hallucinations 3%
  • Dizziness 1%
  • Drowsiness 2%
  • Nausea 2%
  • Sleep difficulty 5%
  • Constipation 8%
  • Muscle weakness 2%
  • Positional low blood pressure 5%
More Mirapex side effects »
How it works
AzilectMirapex
Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.
Type of medication
AzilectMirapex
Prescription onlyPrescription only
Available as
AzilectMirapex
  • Pill
  • Pill
  • Extended release
Used for
AzilectMirapex
Risk factors for serious side effects
AzilectMirapex
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Taking blood pressure-lowering medicines
  • Current kidney problems
  • Parkinson's disease
Detailed Mirapex (pramipexole) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
AzilectMirapex
No food related info.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
Kidneys and liver
AzilectMirapex
No kidneys and liver related info.
  • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
Upsides and benefits
AzilectMirapex
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
Downsides and risks
AzilectMirapex
  • It can cause unusual cravings and changes in behavior in some people.
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
Tips from our pharmacists for people taking the medication
AzilectMirapex
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
  • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
  • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
  • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
  • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
Learn more
More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mirapex (pramipexole)?
Worth itNot sureNot worth it