Compare Azilect vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azilect
(rasagiline)

Rytary
(carbidopa / levodopa)

Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
Reviews & ratings
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Have you used Azilect (rasagiline)?
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Have you used Rytary (carbidopa / levodopa)?
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Side effects
AzilectRytary
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
AzilectRytary
Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
AzilectRytary
Prescription onlyPrescription only
Available as
AzilectRytary
  • Pill
  • Extended release capsule
Used for
AzilectRytary
Risk factors for serious side effects
AzilectRytary
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
  • Taking other medicines for Parkinson's disease
  • Stopping Rytary (carbidopa / levodopa) suddenly
  • History of heart attack
  • High risk for heart attack
Detailed Rytary (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
AzilectRytary
No sleep related info.
  • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
Upsides and benefits
AzilectRytary
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides and risks
AzilectRytary
  • It can cause unusual cravings and changes in behavior in some people.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Tips from our pharmacists for people taking the medication
AzilectRytary
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
  • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
  • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
  • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
Learn more
More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
More about RytarySide effectsAlternativesFDA package insert
Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it