Compare Azilect vs. tolcapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azilect
(rasagiline)

Tasmar
(tolcapone)

Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.Treats Parkinson's disease. Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.
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Prices and coupon for 30 (1mg) tablets of rasagiline
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Prices and coupon for 60 (100mg) tablets of tolcapone
Reviews & ratings
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Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it

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Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it
Side effects
Azilecttolcapone
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
  • Difficulty controlling movement 22%
  • Nausea 12%
  • Sleeping problems 6%
  • Excessive dreaming 4%
  • Muscle cramps 2%
  • Loss of appetite 6%
  • Sleepiness 5%
  • Lightheadedness from standing 3%
  • Diarrhea 8%
More tolcapone side effects »
How it works
Azilecttolcapone
Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.Tasmar (tolcapone) is an enzyme inhibitor that stops levodopa from being broken down. It causes higher levodopa in the brain, which relieves the symptoms of Parkinson's disease.
Type of medication
Azilecttolcapone
Prescription only
Prescription only
Available as
Azilecttolcapone
  • Pill
  • Pill
Used for
Azilecttolcapone
Risk factors for serious side effects
Azilecttolcapone
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
  • ADHD medicines
  • Triptans
  • dextromethorphan
  • pseudoephedrine
  • Taking other medicines for Parkinson's disease
    • Taking other medicines for Parkinson's disease
    • Taking other medicines for Parkinson's disease
    Detailed Azilect (rasagiline) risks & warnings »
    • Liver damage
    • Taking other medicines for Parkinson's disease
      • Taking antipsychotic medicines
        • Taking other medicines for Parkinson's disease
        Detailed Tasmar (tolcapone) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Food
        Azilecttolcapone
        No food related info.
        • Tasmar (tolcapone) can be taken with or without food.
        Upsides and benefits
        Azilecttolcapone
        • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
        • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
        • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
        • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
        • Tasmar (tolcapone) is available as a generic.
        • Tasmar (tolcapone) can be taken with or without food.
        Downsides and risks
        Azilecttolcapone
        • It can cause unusual cravings and changes in behavior in some people.
        • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
        • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
        • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
        • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
        • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
        Tips from our pharmacists for people taking the medication
        Azilecttolcapone
        • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
        • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
        • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
        • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
        • Tasmar (tolcapone) can make you dizzy if you've been sitting or lying down for a while. Be very careful when getting up.
        • Don't drive or do anything requiring concentration until you know how Tasmar (tolcapone) affects you.
        • Your urine might be colored dark orange or brown while taking Tasmar (tolcapone). This is normal.
        • You have to keep taking carbidopa/levodopa with Tasmar (tolcapone). Tasmar (tolcapone) won't work by itself to control your Parkinson's disease.
        • Talk to your doctor if you want to stop taking Tasmar (tolcapone). Stopping it suddenly can be very dangerous.
        Learn more
        More about AzilectSide effectsAlternativesFDA package insert
        Have you used Azilect (rasagiline)?
        Worth itNot sureNot worth it
        More about tolcaponeSide effectsAlternativesFDA package insert
        Have you used Tasmar (tolcapone)?
        Worth itNot sureNot worth it