Compare Azilect vs. tolcapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azilect (rasagiline)

Prescription only

Tasmar (tolcapone)

Prescription only
Treats Parkinson's disease.

Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.

Treats Parkinson's disease.

Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.

Upsides
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
  • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
  • Tasmar (tolcapone) is available as a generic.
  • Tasmar (tolcapone) can be taken with or without food.
Downsides
  • It can cause unusual cravings and changes in behavior in some people.
  • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
  • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
  • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
  • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
  • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$195.29
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$2263.94
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Side effects
9possible side effects
  • Difficulty controlling movement
    18%
  • Headache
    14%
  • Accidental injury
    12%
  • Nausea
    12%
  • Falls
    11%
  • Weight loss
    9%
  • Constipation
    9%
  • Low blood pressure
    9%
  • Joint pain
    8%
See more detailed side effects
10possible side effects
  • Difficulty controlling movement
    42%
  • Nausea
    30%
  • Sleeping problems
    24%
  • Excessive dreaming
    21%
  • Muscle cramps
    19%
  • Loss of appetite
    19%
  • Sleepiness
    18%
  • Uncontrolled muscle spasms
    17%
  • Lightheadedness from standing
    17%
  • Diarrhea
    16%
See more detailed side effects
Risks and warnings
  • Increased blood pressure

    Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 7 more risk factors

  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • Movement problems

    Taking other medicines for Parkinson's disease

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings
  • Liver damage

    Liver damage

  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • Abnormal thinking and mood changes

    Taking antipsychotic medicines

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings