Compare Azithromycin vs. amoxicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(azithromycin)

Amoxil
(amoxicillin)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.
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Coupons for Azithromycin
Best available price for 6 (6 tablets of 250mg) z-paks of azithromycin
Coupons for amoxicillin
Best available price for 30 (500mg) capsules of amoxicillin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.45Azithromycin
Reviews for Azithromycin
74%
of people (All ages) say Azithromycin is worth it
59%
say it works well
11%
say it's a big hassle
909 reviews
Have you used Zithromax (azithromycin)?
Worth itNot sureNot worth it
Reviews for amoxicillin
62%
+12% better vs. Azithromycin
45%
+14% better vs. Azithromycin
14%
+3% better vs. Azithromycin
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Side effects
Azithromycinamoxicillin
  • Diarrhea 5%
  • Nausea 3%
  • Abdominal pain 3%
  • Vomiting 6%
  • Rash 2%
  • Vaginitis 2%
More Azithromycin side effects »

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »
How it works
Azithromycinamoxicillin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.
Type of medication
Azithromycinamoxicillin
Prescription onlyPrescription only
Available as
Azithromycinamoxicillin
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
Used for
Azithromycinamoxicillin
Risk factors for serious side effects
Azithromycinamoxicillin
  • History of liver disease
  • History of myasthenia gravis
Detailed Zithromax (azithromycin) risks & warnings »
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
Azithromycinamoxicillin
  • Can take with or without food.
  • Can be taken with or without food.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
Kidneys and liver
Azithromycinamoxicillin
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
No kidneys and liver related info.
Pain
Azithromycinamoxicillin
  • Can cause abdominal pain, diarrhea, vomiting, and nausea.
No pain related info.
Upsides and benefits
Azithromycinamoxicillin
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
Downsides and risks
Azithromycinamoxicillin
  • Must space out antacids by at least 2 hours.
  • Has to be used with caution in people who've had liver disease.
  • Can't be used in people who've had myasthenia gravis.
  • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • Can cause abdominal pain, diarrhea, vomiting, and nausea.
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
Tips from our pharmacists for people taking the medication
Azithromycinamoxicillin
  • Take the medication exactly how your doctor tells you to.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any antacids with magnesium or aluminum by at least 2 hours.
  • Can take with or without food.
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
Learn more
More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zithromax (azithromycin)?
Worth itNot sureNot worth it
More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it