Compare azithromycin vs. amoxicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax (azithromycin)

Prescription only

Amoxil (amoxicillin)

Prescription only
Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

5.5/ 7 average rating with 909 reviewsforazithromycin
Treats bacterial infections.

Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.

5.0/ 7 average rating with 786 reviewsforamoxicillin
Upsides
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
Downsides
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
Used for
Dosage forms
  • Pill
  • Liquid
  • Extended-release liquid
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
Price
Lowest price near you
$9.89
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Lowest price near you
$4
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Reviews
909 
74%
think this treatment is worth it
59%
think this treatment works well
11%
think this treatment is a hassle

Have you used Zithromax (azithromycin)?

Leave a review
786 
62%
think this treatment is worth it
45%
think this treatment works well
14%
think this treatment is a hassle

Have you used Amoxil (amoxicillin)?

Leave a review
Side effects
3possible side effects
  • Vomiting
    5%
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Amoxil (amoxicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    History of liver disease

  • Myasthenia gravis

    Myasthenia gravis

  • Abnormal heartbeat

    QT prolongation

    ...and 4 more risk factors

See more detailed risks and warnings
  • Interaction with birth control

    Using oral birth control pills

  • Severe diarrhea

    Taking Amoxil (amoxicillin) for a long time

  • Severe allergic reaction

    History of penicillin allergies

  • New infections while taking Amoxil (amoxicillin)

    Weakened immune system

    ...and 1 more risk factors

  • Rash

    Mononucleosis

See more detailed risks and warnings