Compare Azithromycin vs. Amoxicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(Azithromycin)

Amoxil
(Amoxicillin)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.443093922651934Azithromycin
Reviews for Zithromax (Azithromycin)
74%
of people say Zithromax (Azithromycin) is worth it
59%
say it works well
11%
say it's a big hassle
Reviews for Amoxil (Amoxicillin)
62%
12% vs. Zithromax (Azithromycin)
45%
14% vs. Zithromax (Azithromycin)
14%
3% vs. Zithromax (Azithromycin)
Side effects
AzithromycinAmoxicillin

The Azithromycin FDA package insert doesn’t have numbers about how common side effects are.

More about Azithromycin side effects »

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »
How it works
AzithromycinAmoxicillin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.
Type of medication
AzithromycinAmoxicillin
Antibiotic
Macrolide
Prescription only
Antibiotic
Penicillin
Prescription only
Available as
AzithromycinAmoxicillin
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
AzithromycinAmoxicillin
Risk factors for serious side effects
AzithromycinAmoxicillin
      • History of liver disease
      • History of myasthenia gravis
      Detailed Zithromax (Azithromycin) risks & warnings »
      • Long antibiotic treatment period
      • History of penicillin allergies
      • Using oral birth control pills
        Detailed Amoxil (Amoxicillin) risks & warnings »
        Pregnancy category
        AzithromycinAmoxicillin
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Can be taken with or without food.
        • Can take with or without food.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AzithromycinAmoxicillin
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Can be taken with or without food.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        Downsides and risks
        AzithromycinAmoxicillin
        • Must space out antacids by at least 2 hours.
        • Has to be used with caution in people who've had liver disease.
        • Can't be used in people who've had myasthenia gravis.
        • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
        • Can cause abdominal pain, diarrhea, vomiting, and nausea.
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        Tips from our pharmacists for people taking the medication
        AzithromycinAmoxicillin
        • Take the medication exactly how your doctor tells you to.
        • Can cause diarrhea, nausea or vomiting.
        • Space out any antacids with magnesium or aluminum by at least 2 hours.
        • Can take with or without food.
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        Learn more
        More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert