Compare Azithromycin vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(azithromycin)

Augmentin
(amoxicillin / clavulanate)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.45Azithromycin
Reviews for Azithromycin
74%
of people (All ages) say Azithromycin is worth it
59%
say it works well
11%
say it's a big hassle
909 reviews
Have you used Zithromax (azithromycin)?
Worth itNot sureNot worth it
Reviews for Augmentin
68%
+6% better vs. Azithromycin
52%
+7% better vs. Azithromycin
13%
+2% better vs. Azithromycin
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Side effects
AzithromycinAugmentin
  • Diarrhea 5%
  • Nausea 3%
  • Abdominal pain 3%
  • Vomiting 6%
  • Rash 2%
  • Vaginitis 2%
More Azithromycin side effects »
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »
How it works
AzithromycinAugmentin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.
Type of medication
AzithromycinAugmentin
Prescription onlyPrescription only
Available as
AzithromycinAugmentin
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for
AzithromycinAugmentin
Risk factors for serious side effects
AzithromycinAugmentin
  • History of liver disease
  • History of myasthenia gravis
Detailed Zithromax (azithromycin) risks & warnings »
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
AzithromycinAugmentin
  • Can take with or without food.
  • Can be taken with or without food.
  • Take with food if you're having upset stomach.
Kidneys and liver
AzithromycinAugmentin
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
  • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
Pain
AzithromycinAugmentin
  • Can cause abdominal pain, diarrhea, vomiting, and nausea.
No pain related info.
Upsides and benefits
AzithromycinAugmentin
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
Downsides and risks
AzithromycinAugmentin
  • Must space out antacids by at least 2 hours.
  • Has to be used with caution in people who've had liver disease.
  • Can't be used in people who've had myasthenia gravis.
  • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • Can cause abdominal pain, diarrhea, vomiting, and nausea.
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
Tips from our pharmacists for people taking the medication
AzithromycinAugmentin
  • Take the medication exactly how your doctor tells you to.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any antacids with magnesium or aluminum by at least 2 hours.
  • Can take with or without food.
  • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
  • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
  • Take with food if you're having upset stomach.
  • Store the liquid in the fridge and throw away after 10 days.
  • Shake the suspension thoroughly before using each dose.
Learn more
More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zithromax (azithromycin)?
Worth itNot sureNot worth it
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it