Compare Azithromycin vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(Azithromycin)

Augmentin
(Amoxicillin / Clavulanate)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.443093922651934Azithromycin
Reviews for Zithromax (Azithromycin)
74%
of people say Zithromax (Azithromycin) is worth it
59%
say it works well
11%
say it's a big hassle
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
6% vs. Zithromax (Azithromycin)
52%
7% vs. Zithromax (Azithromycin)
13%
2% vs. Zithromax (Azithromycin)
Side effects
AzithromycinAugmentin

The Azithromycin FDA package insert doesn’t have numbers about how common side effects are.

More about Azithromycin side effects »

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »
How it works
AzithromycinAugmentin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.
Type of medication
AzithromycinAugmentin
Antibiotic
Macrolide
Prescription only
Antibiotic
Penicillin
Prescription only
Available as
AzithromycinAugmentin
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for (click to learn more)
AzithromycinAugmentin
Risk factors for serious side effects
AzithromycinAugmentin
      • History of liver disease
      • History of myasthenia gravis
      Detailed Zithromax (Azithromycin) risks & warnings »
      • Mononucleosis
        • History of liver disease
          Detailed Augmentin (Amoxicillin / Clavulanate) risks & warnings »
          Pregnancy category
          AzithromycinAugmentin
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Can be taken with or without food.
          • Can take with or without food.
          • Should be taken with food since it can cause stomach upset.
          • Take each dose with a meal since it may cause an upset stomach.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AzithromycinAugmentin
          • Can be taken with or without food.
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          Downsides and risks
          AzithromycinAugmentin
          • Must space out antacids by at least 2 hours.
          • Has to be used with caution in people who've had liver disease.
          • Can't be used in people who've had myasthenia gravis.
          • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
          • Can cause abdominal pain, diarrhea, vomiting, and nausea.
          • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
          • Should be taken with food since it can cause stomach upset.
          • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
          Tips from our pharmacists for people taking the medication
          AzithromycinAugmentin
          • Take the medication exactly how your doctor tells you to.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any antacids with magnesium or aluminum by at least 2 hours.
          • Can take with or without food.
          • Take this medication exactly as your doctor tells you to.
          • Take each dose with a meal since it may cause an upset stomach.
          • If you are taking birth control pills, this can make it less effective.
          • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
          Learn more
          More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
          More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert