Compare Azithromycin vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(Azithromycin)

Cleocin T
(Clindamycin Phosphate)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.443093922651934Azithromycin
Reviews for Zithromax (Azithromycin)
74%
of people say Zithromax (Azithromycin) is worth it
59%
say it works well
11%
say it's a big hassle
Reviews for Cleocin T (Clindamycin Phosphate)
57%
17% vs. Zithromax (Azithromycin)
43%
16% vs. Zithromax (Azithromycin)
20%
9% vs. Zithromax (Azithromycin)
Side effects
AzithromycinCleocin

The Azithromycin FDA package insert doesn’t have numbers about how common side effects are.

More about Azithromycin side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »
How it works
AzithromycinCleocin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AzithromycinCleocin
Antibiotic
Macrolide
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
AzithromycinCleocin
  • Pill
  • Liquid
  • Eye drops
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for (click to learn more)
AzithromycinCleocin
Risk factors for serious side effects
AzithromycinCleocin
      • History of liver disease
      • History of myasthenia gravis
      Detailed Zithromax (Azithromycin) risks & warnings »
        • History of liver disease
          Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
          Pregnancy category
          AzithromycinCleocin
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Can be taken with or without food.
          • Can take with or without food.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • Can be taken with or without food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AzithromycinCleocin
          • Available in different forms: tablet, capsule, and suspension.
          • Available in generic.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Available in generic.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          Downsides and risks
          AzithromycinCleocin
          • Must space out antacids by at least 2 hours.
          • Has to be used with caution in people who've had liver disease.
          • Can't be used in people who've had myasthenia gravis.
          • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
          • Can cause abdominal pain, diarrhea, vomiting, and nausea.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          Tips from our pharmacists for people taking the medication
          AzithromycinCleocin
          • Take the medication exactly how your doctor tells you to.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any antacids with magnesium or aluminum by at least 2 hours.
          • Can take with or without food.
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Learn more
          More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert