Compare Azithromycin vs. Levaquin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(Azithromycin)

Levaquin
(Levofloxacin)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.443093922651934Azithromycin
Reviews for Zithromax (Azithromycin)
74%
of people say Zithromax (Azithromycin) is worth it
59%
say it works well
11%
say it's a big hassle
Reviews for Levaquin (Levofloxacin)
54%
20% vs. Zithromax (Azithromycin)
39%
20% vs. Zithromax (Azithromycin)
29%
18% vs. Zithromax (Azithromycin)
Side effects
AzithromycinLevaquin

The Azithromycin FDA package insert doesn’t have numbers about how common side effects are.

More about Azithromycin side effects »

The Levaquin FDA package insert doesn’t have numbers about how common side effects are.

More about Levaquin side effects »
How it works
AzithromycinLevaquin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AzithromycinLevaquin
Antibiotic
Macrolide
Prescription only
Antibiotic
Fluoroquinolone
Prescription only
Available as
AzithromycinLevaquin
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Liquid
Used for (click to learn more)
AzithromycinLevaquin
Risk factors for serious side effects
AzithromycinLevaquin
      • History of liver disease
      • History of myasthenia gravis
      Detailed Zithromax (Azithromycin) risks & warnings »
      • Over 60 years of age
      • On long-term steroid use
      • Heart, kidney, or lung transplant
        • History of liver disease
        • Seizures
            • Diabetes
            • Taking medications for diabetes
                Detailed Levaquin (Levofloxacin) risks & warnings »
                Pregnancy category
                AzithromycinLevaquin
                BFDA pregnancy category (Probably safe)

                Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Can be taken with or without food.
                • Can take with or without food.
                No specific food-related info.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                AzithromycinLevaquin
                • Can be taken with or without food.
                • Available in generic.
                • Available in different forms: tablet, capsule, and suspension.
                • Used to treat many types of bacterial infections.
                • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
                • Available in generic.
                • Available in different forms: tablet, capsule, and suspension.
                • Used to treat many types of bacterial infections.
                • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
                Downsides and risks
                AzithromycinLevaquin
                • Must space out antacids by at least 2 hours.
                • Has to be used with caution in people who've had liver disease.
                • Can't be used in people who've had myasthenia gravis.
                • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
                • Can cause abdominal pain, diarrhea, vomiting, and nausea.
                • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
                • Levofloxacin can make your skin more sensitive to the sun.
                • Can't be used if you've ever had myasthenia gravis.
                • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
                • Can cause changes in taste, headaches, and insomnia.
                Tips from our pharmacists for people taking the medication
                AzithromycinLevaquin
                • Take the medication exactly how your doctor tells you to.
                • Space out any antacids with magnesium or aluminum by at least 2 hours.
                • Can take with or without food.
                • Can cause diarrhea, nausea or vomiting.
                • If you notice pain in your Achilles tendons, contact your doctor.
                • Wear sunscreen if you're going to be out in the sun.
                • Take the medication exactly how the doctor tells you to.
                • Take this medication with plenty of fluids.
                • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
                • Can cause changes in taste, headaches and insomnia.
                • Can cause diarrhea, nausea or vomiting.
                Learn more
                More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
                More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert