Compare azithromycin vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax (azithromycin)

Prescription only

Solodyn (Minocycline)

Prescription only
Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

4.0/ 5 average rating with 909 reviewsforazithromycin
Treats bacterial infections.

Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.

4.0/ 5 average rating with 17 reviewsforMinocycline
Upsides
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Used for
Dosage forms
  • Pill
  • Liquid
  • Extended-release liquid
  • Pill
  • Extended release
  • Extended release capsule
Price
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Reviews
909 reviews so far
74%
saidit'sworth it
59%
saiditworked well
11%
saidit'sa big hassle

Have you used Zithromax (azithromycin)?

Leave a review
17 reviews so far
53%
saidit'sworth it
59%
saiditworked well
18%
saidit'sa big hassle

Have you used Solodyn (Minocycline)?

Leave a review
Side effects
3possible side effects
  • Vomiting
    5%
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Solodyn (Minocycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Diarrhea caused by bacteria (Clostridium difficile)
  • Liver damage
    • History of liver disease
  • Myasthenia gravis
    • Myasthenia gravis
  • Serious allergic reaction
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
    • Elderly
See more detailed risks and warnings
  • Changes in teeth
    • Age 8 years or younger
  • Decreased effectiveness of birth control pills
    • Using oral birth control pills
  • Diarrhea from a superinfection (an infection that happens after, or in addition to, an earlier infection)
    • Long antibiotic treatment period
  • Rash
  • Sunburn
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings