Compare Azithromycin vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax
(azithromycin)

Solodyn
(minocycline)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.45Azithromycin
Reviews for Azithromycin
74%
of people (All ages) say Azithromycin is worth it
59%
say it works well
11%
say it's a big hassle
909 reviews
Have you used Zithromax (azithromycin)?
Worth itNot sureNot worth it
Reviews for Minocycline
53%
+21% better vs. Azithromycin
59%
Same vs. Azithromycin
18%
+7% better vs. Azithromycin
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it
Side effects
AzithromycinMinocycline
  • Diarrhea 5%
  • Nausea 3%
  • Abdominal pain 3%
  • Vomiting 6%
  • Rash 2%
  • Vaginitis 2%
More Azithromycin side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
AzithromycinMinocycline
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AzithromycinMinocycline
Prescription onlyPrescription only
Available as
AzithromycinMinocycline
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Extended release
  • Extended release capsule
Used for
AzithromycinMinocycline
Risk factors for serious side effects
AzithromycinMinocycline
  • History of liver disease
  • History of myasthenia gravis
Detailed Zithromax (azithromycin) risks & warnings »
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Solodyn (minocycline) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
AzithromycinMinocycline
No price related info.
  • Available as a generic, so it should be reasonably priced.
Food
AzithromycinMinocycline
  • Can take with or without food.
  • Can be taken with or without food.
No food related info.
Kidneys and liver
AzithromycinMinocycline
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
No kidneys and liver related info.
Pain
AzithromycinMinocycline
  • Can cause abdominal pain, diarrhea, vomiting, and nausea.
No pain related info.
Upsides and benefits
AzithromycinMinocycline
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides and risks
AzithromycinMinocycline
  • Must space out antacids by at least 2 hours.
  • Has to be used with caution in people who've had liver disease.
  • Can't be used in people who've had myasthenia gravis.
  • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • Can cause abdominal pain, diarrhea, vomiting, and nausea.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Tips from our pharmacists for people taking the medication
AzithromycinMinocycline
  • Take the medication exactly how your doctor tells you to.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any antacids with magnesium or aluminum by at least 2 hours.
  • Can take with or without food.
  • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
  • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
  • Can stain your teeth, tongue and gums, but this is temporary.
  • Take this exactly how your doctor or pharmacist tells you until it's all gone.
  • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
Learn more
More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zithromax (azithromycin)?
Worth itNot sureNot worth it
More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it