Compare azithromycin vs. Penicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zithromax (azithromycin)

Prescription only
Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

5.5/ 7 average rating with 909 reviewsforazithromycin
Kills bacteria.

Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.

5.3/ 7 average rating with 1297 reviewsforPenicillin
Upsides
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
  • Available in generic.
  • Available in different forms: tablet, capsule and suspension.
  • Used to treat many types of bacterial infections.
Downsides
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
  • Can make birth control pills less effective.
  • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
Used for
Dosage forms
  • Pill
  • Liquid
  • Extended-release liquid
  • Pill
Price
Lowest price near you
$9.89
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Reviews
909 
74%
think this treatment is worth it
59%
think this treatment works well
11%
think this treatment is a hassle

Have you used Zithromax (azithromycin)?

Leave a review
1297 
71%
think this treatment is worth it
52%
think this treatment works well
12%
think this treatment is a hassle

Have you used Penicillin Vk (Penicillin)?

Leave a review
Side effects
3possible side effects
  • Vomiting
    5%
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Penicillin Vk (Penicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    History of liver disease

  • Myasthenia gravis

    Myasthenia gravis

  • Abnormal heartbeat

    QT prolongation

    ...and 4 more risk factors

See more detailed risks and warnings
  • Allergic reactions

    Prior severe allergic reaction to Penicillin Vk (Penicillin)

See more detailed risks and warnings