Compare baclofen vs. Detrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Detrol
(tolterodine)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Treats overactive bladder. Detrol (tolterodine) is a good treatment for overactive bladder after exercises and other methods to control it haven't worked.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for baclofen
61%
of people (All ages) say baclofen is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it

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Have you used Detrol (tolterodine)?
Worth itNot sureNot worth it
Side effects
baclofenDetrol
  • Drowsiness 27%
More baclofen side effects »
  • Dry mouth 25%
  • Headache 2%
  • Constipation 3%
  • Dizziness 2%
  • Stomach pain 2%
  • Tiredness 1%
  • Diarrhea 1%
  • Indigestion 3%
  • Drowsiness 1%
  • Dry eyes 1%
More Detrol side effects »
How it works
baclofenDetrol
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Detrol (tolterodine) is an antimuscarinic. It helps people control the urge to urinate by relaxing the bladder muscles and stopping them from spasming.
Type of medication
baclofenDetrol
Prescription onlyPrescription only
Available as
baclofenDetrol
  • Pill
  • Pill
  • Extended release
Used for
baclofenDetrol
Risk factors for serious side effects
baclofenDetrol
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • People age 65 or older
  • Glaucoma
  • History of bladder problems
Detailed Detrol (tolterodine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
baclofenDetrol
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
Food
baclofenDetrol
No food related info.
  • You can take Detrol (tolterodine) with or without food.
Kidneys and liver
baclofenDetrol
No kidneys and liver related info.
  • If you have liver or kidney problems, talk to your doctor before starting Detrol (tolterodine). You might have to use a lower dose, or you might not be able to take Detrol (tolterodine) at all.
Sleep
baclofenDetrol
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You can get drowsy or dizzy on Detrol (tolterodine). Do not stand or sit up too quickly if you've been sitting or lying down for a while.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
Upsides and benefits
baclofenDetrol
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Detrol (tolterodine) is effective at treating overactive bladder by lowering the urge to urinate, and controlling urination.
  • The tablet is available as a generic in both extended and immediate release, so you can take it once or twice a day.
Downsides and risks
baclofenDetrol
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
  • Detrol (tolterodine) can cause severe dry mouth and eyes and constipation.
  • Generally not recommended if you are 65 or older.
  • Do not use if you have uncontrolled narrow-angle glaucoma.
Tips from our pharmacists for people taking the medication
baclofenDetrol
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Detrol (tolterodine) can take up to 4 weeks before you notice any changes.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
  • You can get drowsy or dizzy on Detrol (tolterodine). Do not stand or sit up too quickly if you've been sitting or lying down for a while.
  • You can take Detrol (tolterodine) with or without food.
  • Do not break, crush or chew extended-release capsules.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
More about DetrolSide effectsAlternativesFDA package insert
Have you used Detrol (tolterodine)?
Worth itNot sureNot worth it