Compare baclofen vs. Flexeril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Flexeril
(cyclobenzaprine)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.
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Coupons for baclofen
Best available price for 90 (10mg) tablets of baclofen
Coupons for Flexeril
Best available price for 90 (10mg) tablets of cyclobenzaprine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for baclofen
61%
of people (All ages) say baclofen is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
Reviews for Flexeril
66%
-5% worse vs. baclofen
37%
+18% better vs. baclofen
14%
-1% worse vs. baclofen
1064 reviews
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it
Side effects
baclofenFlexeril
  • Drowsiness 27%
More baclofen side effects »
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Drowsiness 100%
  • Headache nos 17%
  • Dry throat 8%
  • Acne nos 6%
  • Disturbance in attention 6%
More Flexeril side effects »
How it works
baclofenFlexeril
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.
Type of medication
baclofenFlexeril
Prescription onlyPrescription only
Available as
baclofenFlexeril
  • Pill
  • Pill
  • Extended release
Used for
baclofenFlexeril
Risk factors for serious side effects
baclofenFlexeril
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (cyclobenzaprine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
baclofenFlexeril
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Don't drink alcohol while on this medication.
Pain
baclofenFlexeril
No pain related info.
  • Can relieve pain associated with muscle spasms.
Sleep
baclofenFlexeril
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
Upsides and benefits
baclofenFlexeril
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
Downsides and risks
baclofenFlexeril
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
Tips from our pharmacists for people taking the medication
baclofenFlexeril
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it