Compare baclofen vs. Flexeril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relaxes your muscles. Lioresal (Baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others.Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.
How it works
Lioresal (Baclofen) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.
Type of medication
Muscle relaxerPrescription only
Muscle relaxerPrescription only
Available as
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Lioresal (Baclofen)
of people say Lioresal (Baclofen) is worth it
say it works well
say it's a big hassle
Reviews for Flexeril (Cyclobenzaprine)
+1% vs. Lioresal (Baclofen)
24% vs. Lioresal (Baclofen)
+8% vs. Lioresal (Baclofen)
Side effects

We haven’t found good data for baclofen side effects.

FDA side effect reports for baclofen »
  • Indigestion 3%
  • Fatigue 1%
More Flexeril side effects »
Risk factors for serious side effects
  • Stopping Lioresal (Baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
  • Using other medicines that can cause seizures
  • History of seizures
  • Alcoholism
  • Eating disorders
  • Brain infections
Detailed Lioresal (Baclofen) risks & warnings »
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (Cyclobenzaprine) risks & warnings »
Pregnancy category
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
  • Don't drink alcohol while using this.
  • Don't drink alcohol while on this medication.
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • Lioresal (Baclofen) is effective for treating muscle spasms, as well as being an effective muscle relaxant.
  • Can be used long term.
  • Relieves pain associated with muscle spasms.
  • A better option for seniors compared to other muscle relaxants since it has less side effects than the other meds.
  • Lioresal (Baclofen) is available as a generic and is a relatively inexpensive medication.
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
Downsides and risks
  • If taking regularly, you shouldn't stop taking Lioresal (Baclofen) abruptly. You'll need to get off of it slowly.
  • Be careful if taking other drugs that affect your ability to stay awake, since Lioresal (Baclofen) can make you much more tired.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
Tips from our pharmacists for people taking the medication
  • Can cause dizziness and fatigue.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken as needed or 'around-the-clock'. Ask your doctor about what'll work best for you.
  • If taking regularly, you need to work with your doctor to get off the medication slowly (also called tapering) to avoid withdrawal symptoms.
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert