Compare Baclofen vs. Flexeril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(Baclofen)

Flexeril
(Cyclobenzaprine)

Relaxes your muscles. Lioresal (Baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others.Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79Baclofen
Reviews for Lioresal (Baclofen)
61%
of people (All ages) say Lioresal (Baclofen) is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (Baclofen)?
Worth itNot sureNot worth it
Reviews for Flexeril (Cyclobenzaprine)
66%
+5% better vs. Lioresal (Baclofen)
37%
-18% worse vs. Lioresal (Baclofen)
14%
+1% better vs. Lioresal (Baclofen)
1064 reviews
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it
Side effects
BaclofenFlexeril

We haven’t found good data for Baclofen side effects.

FDA side effect reports for Baclofen »
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Drowsiness 100%
  • Headache nos 17%
  • Dry throat 8%
  • Acne nos 6%
  • Disturbance in attention 6%
More Flexeril side effects »
How it works
BaclofenFlexeril
Lioresal (Baclofen) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.
Type of medication
BaclofenFlexeril
Prescription only
Prescription only
Available as
BaclofenFlexeril
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
Used for
BaclofenFlexeril
Risk factors for serious side effects
BaclofenFlexeril
  • Stopping Lioresal (Baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
  • Using other medicines that can cause seizures
  • History of seizures
  • Alcoholism
  • Eating disorders
  • Brain infections
Detailed Lioresal (Baclofen) risks & warnings »
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (Cyclobenzaprine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
BaclofenFlexeril
  • Don't drink alcohol while using this.
  • Don't drink alcohol while on this medication.
Pain
BaclofenFlexeril
  • Relieves pain associated with muscle spasms.
  • Can relieve pain associated with muscle spasms.
Sleep
BaclofenFlexeril
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
Upsides and benefits
BaclofenFlexeril
  • Lioresal (Baclofen) is effective for treating muscle spasms, as well as being an effective muscle relaxant.
  • Can be used long term.
  • Relieves pain associated with muscle spasms.
  • A better option for seniors compared to other muscle relaxants since it has less side effects than the other meds.
  • Lioresal (Baclofen) is available as a generic and is a relatively inexpensive medication.
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
Downsides and risks
BaclofenFlexeril
  • If taking regularly, you shouldn't stop taking Lioresal (Baclofen) abruptly. You'll need to get off of it slowly.
  • Be careful if taking other drugs that affect your ability to stay awake, since Lioresal (Baclofen) can make you much more tired.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
Tips from our pharmacists for people taking the medication
BaclofenFlexeril
  • Can cause dizziness and fatigue.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken as needed or 'around-the-clock'. Ask your doctor about what'll work best for you.
  • If taking regularly, you need to work with your doctor to get off the medication slowly (also called tapering) to avoid withdrawal symptoms.
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
Learn more
More about BaclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (Baclofen)?
Worth itNot sureNot worth it
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it