Compare baclofen vs. Myrbetriq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Myrbetriq
(mirabegron)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Treats overactive bladder. Myrbetriq (mirabegron) is a good treatment for overactive bladder with the least chance for dry mouth and constipation, but talk to your doctor if you have high blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for baclofen
61%
of people (All ages) say baclofen is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
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Have you used Myrbetriq (mirabegron)?
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Side effects
baclofenMyrbetriq
  • Drowsiness 27%
More baclofen side effects »
  • High blood pressure 3%
  • Common cold symptoms 1%
  • Urinary tract infection 2%
  • Constipation 1%
  • Joint pain 1%
  • Rapid heart beat 1%
More Myrbetriq side effects »
How it works
baclofenMyrbetriq
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Myrbetriq (mirabegron) is a beta-3 receptor agonist. It activates the receptor in your bladder, causing the bladder muscles to relax. This allows you to hold more urine and go to the bathroom less often.
Type of medication
baclofenMyrbetriq
Prescription onlyPrescription only
Available as
baclofenMyrbetriq
  • Pill
  • Extended release
Used for
baclofenMyrbetriq
Risk factors for serious side effects
baclofenMyrbetriq
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
  • Untreated high blood pressure
  • Bladder outlet obstruction
Detailed Myrbetriq (mirabegron) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
baclofenMyrbetriq
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
No alcohol related info.
Food
baclofenMyrbetriq
No food related info.
  • You can take Myrbetriq (mirabegron) with or without food. If it upsets your stomach, take it with food.
Kidneys and liver
baclofenMyrbetriq
No kidneys and liver related info.
  • Not recommended if you have severe liver or kidney disease.
Sleep
baclofenMyrbetriq
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Myrbetriq (mirabegron) causes less drowsiness and constipation than other medicines for overactive bladder.
Upsides and benefits
baclofenMyrbetriq
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Myrbetriq (mirabegron) helps you to have better control over your urination.
  • Myrbetriq (mirabegron) causes less drowsiness and constipation than other medicines for overactive bladder.
  • May be used if you have glaucoma.
  • Myrbetriq (mirabegron) may be safer to use if you are over 65 years old.
Downsides and risks
baclofenMyrbetriq
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Myrbetriq (mirabegron) might raise your blood pressure.
  • If you have an obstruction in your bladder, Myrbetriq (mirabegron) might make you retain more urine.
  • Myrbetriq (mirabegron) may be very expensive depending on your insurance.
  • Not recommended if you have severe liver or kidney disease.
Tips from our pharmacists for people taking the medication
baclofenMyrbetriq
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Myrbetriq (mirabegron) is a long-acting medicine. Do not crush, break or chew it.
  • Drink enough water to keep hydrated. Not drinking enough water on hot days can increase your chances of dehydration or heat stroke.
  • You can take Myrbetriq (mirabegron) with or without food. If it upsets your stomach, take it with food.
  • Drinking too much caffeine in coffee or sodas can make the side effects worse.
  • Check your blood pressure regularly while on Myrbetriq (mirabegron).
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
More about MyrbetriqSide effectsAlternativesFDA package insert
Have you used Myrbetriq (mirabegron)?
Worth itNot sureNot worth it