Compare baclofen vs. Oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Oxytrol
(oxybutynin)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Treats an overactive bladder. Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for baclofen
61%
of people (All ages) say baclofen is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it

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Have you used Oxytrol (oxybutynin)?
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Side effects
baclofenOxybutynin
  • Drowsiness 27%
More baclofen side effects »

We haven’t found good data for Oxybutynin side effects.

FDA side effect reports for Oxybutynin »
How it works
baclofenOxybutynin
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Oxytrol (Oxybutynin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.
Type of medication
baclofenOxybutynin
Prescription onlyPrescription only
Available as
baclofenOxybutynin
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
Used for
baclofenOxybutynin
Risk factors for serious side effects
baclofenOxybutynin
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Oxytrol (oxybutynin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
baclofenOxybutynin
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
Food
baclofenOxybutynin
No food related info.
  • Can be taken with or without food.
Sleep
baclofenOxybutynin
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Oxytrol (Oxybutynin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Oxytrol (Oxybutynin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
Upsides and benefits
baclofenOxybutynin
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
Downsides and risks
baclofenOxybutynin
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
Tips from our pharmacists for people taking the medication
baclofenOxybutynin
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
More about OxybutyninSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oxytrol (oxybutynin)?
Worth itNot sureNot worth it