Compare baclofen vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Skelaxin
(metaxalone)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Coming soon.
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Coupons for baclofen
Best available price for 90 (10mg) tablets of baclofen
Coupons for Skelaxin
Best available price for 30 (800mg) tablets of metaxalone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for Lioresal (baclofen)
61%
of people (All ages) say Lioresal (baclofen) is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
Reviews for Skelaxin (metaxalone)
Not enough review data. Review it!
+39% better vs. Lioresal (baclofen)
Not enough review data. Review it!
-5% worse vs. Lioresal (baclofen)
Not enough review data. Review it!
+15% better vs. Lioresal (baclofen)
Have you used Skelaxin (metaxalone)?
Worth itNot sureNot worth it
Side effects
baclofenSkelaxin
  • Drowsiness 27%
More baclofen side effects »

We haven’t found good data for Skelaxin side effects.

FDA side effect reports for Skelaxin »
How it works
baclofenSkelaxin
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Coming soon.
Type of medication
baclofenSkelaxin
Prescription only
Available as
baclofenSkelaxin
  • Pill
  • Pill
Used for
baclofenSkelaxin
  • Musculoskeletal Pain
Risk factors for serious side effects
baclofenSkelaxin
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Alcohol
    baclofenSkelaxin
    • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
    No alcohol related info.
    Sleep
    baclofenSkelaxin
    • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    No sleep related info.
    Upsides and benefits
    baclofenSkelaxin
    • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
    • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
    Coming soon
    Downsides and risks
    baclofenSkelaxin
    • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
    • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
    • Lioresal (baclofen) can make you sleepy.
    • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
    Coming soon
    Tips from our pharmacists for people taking the medication
    baclofenSkelaxin
    • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
    • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
    Coming soon
    Learn more
    More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lioresal (baclofen)?
    Worth itNot sureNot worth it
    More about SkelaxinSide effectsReviews & ratingsFDA package insert
    Have you used Skelaxin (metaxalone)?
    Worth itNot sureNot worth it