Compare baclofen vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

3.5/ 5 average rating with 33 reviewsforbaclofen
Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

Upsides
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
Downsides
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
Used for
  • Musculoskeletal pain
Dosage forms
  • Pill
  • Pill
Price
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Reviews
33 reviews so far
61%
saidit'sworth it
55%
saiditworked well
15%
saidit'sa big hassle

Have you used Lioresal (baclofen)?

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Side effects
1possible side effects
  • Drowsiness
    63%
See more detailed side effects
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Withdrawal symptoms
    • Stopping Lioresal (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Serotonin syndrome
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
  • Liver damage
    • History of liver disease
  • Liver or Kidney problems
    • History of liver disease
    • History of kidney disease
See more detailed risks and warnings