Compare baclofen vs. Soma

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Soma
(carisoprodol)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Relaxes your muscles. Soma (carisoprodol) is used for muscle spasms and muscle pain but it's not considered a first-choice treatment and not meant for long-term therapy.
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Coupons for baclofen
Best available price for 90 (10mg) tablets of baclofen
Coupons for Soma
Best available price for 90 (350mg) tablets of soma
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for baclofen
61%
of people (All ages) say baclofen is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
Reviews for Soma
61%
Same vs. baclofen
39%
+16% better vs. baclofen
9%
-6% worse vs. baclofen
220 reviews
Have you used Soma (carisoprodol)?
Worth itNot sureNot worth it
Side effects
baclofenSoma
  • Drowsiness 27%
More baclofen side effects »
  • Drowsiness 7%
  • Dizziness 6%
  • Headache 3%
More Soma side effects »
How it works
baclofenSoma
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Soma (carisoprodol) is a muscle relaxant. It works in the brain to help calm down muscle spasms.
Type of medication
baclofenSoma
Prescription onlyPrescription only
Available as
baclofenSoma
  • Pill
  • Pill
Used for
baclofenSoma
Risk factors for serious side effects
baclofenSoma
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Elderly
  • Prior history of drug abuse
Detailed Soma (carisoprodol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
baclofenSoma
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Don't drink alcohol while on this medication.
Sleep
baclofenSoma
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
baclofenSoma
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Patients treated with Soma (carisoprodol) experienced improvement in function.
  • Available in generic.
  • Available in two different strengths.
Downsides and risks
baclofenSoma
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Not first choice for treating muscle spasms or muscle pain, because it can cause dependence.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy, because it hasn't been shown to be effective after taking it for a short period.
  • Can cause withdrawal symptoms if you stop taking it suddenly.
Tips from our pharmacists for people taking the medication
baclofenSoma
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Take the medication at the same time each day.
  • Soma (carisoprodol) is not meant to be used long-term. It should be used for only 2 to 3 weeks maximum.
  • Can cause dizziness, fatigue, and sleepiness.
  • Don't drink alcohol while on this medication.
  • Soma (carisoprodol) can cause stomach pain, nausea and vomiting.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
More about SomaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Soma (carisoprodol)?
Worth itNot sureNot worth it