Compare baclofen vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lioresal
(baclofen)

Zanaflex
(tizanidine)

Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.
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Coupons for baclofen
Best available price for 90 (10mg) tablets of baclofen
Coupons for Zanaflex
Best available price for 90 (4mg) tablets of tizanidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.79baclofen
Reviews for Lioresal (baclofen)
61%
of people (All ages) say Lioresal (baclofen) is worth it
55%
say it works well
15%
say it's a big hassle
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
Reviews for Zanaflex (tizanidine)
81%
+20% better vs. Lioresal (baclofen)
73%
+18% better vs. Lioresal (baclofen)
19%
-4% worse vs. Lioresal (baclofen)
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it
Side effects
baclofenZanaflex
  • Drowsiness 27%
More baclofen side effects »

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »
How it works
baclofenZanaflex
Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.
Type of medication
baclofenZanaflex
Prescription only
Prescription only
Available as
baclofenZanaflex
  • Pill
  • Pill
Used for
baclofenZanaflex
Risk factors for serious side effects
baclofenZanaflex
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
Detailed Zanaflex (tizanidine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
baclofenZanaflex
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Don't drink alcohol while using this.
Food
baclofenZanaflex
No food related info.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Need to be consistent every day in taking this with or without food.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
Sleep
baclofenZanaflex
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
Upsides and benefits
baclofenZanaflex
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Relieves muscle spasms well.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
Downsides and risks
baclofenZanaflex
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
  • Can't stop taking this abruptly if you use it regularly.
Tips from our pharmacists for people taking the medication
baclofenZanaflex
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
More about ZanaflexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it