Compare Bactrim vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(sulfamethoxazole / trimethoprim)

(amoxicillin / clavulanate)

Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for
Prices and coupon for 20 (800mg/160mg) tablets of sulfamethoxazole / trimethoprim
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Bactrim (sulfamethoxazole / trimethoprim)
of people (All ages) say Bactrim (sulfamethoxazole / trimethoprim) is worth it
say it works well
say it's a big hassle
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Reviews for Augmentin (amoxicillin / clavulanate)
+9% better vs. Bactrim (sulfamethoxazole / trimethoprim)
+3% better vs. Bactrim (sulfamethoxazole / trimethoprim)
+9% better vs. Bactrim (sulfamethoxazole / trimethoprim)
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Side effects

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »
How it works
Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for
Risk factors for serious side effects
          • Elderly
          • Taking other medicines that lower kidney function
          Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
          • History of penicillin allergies
            • Taking Augmentin (amoxicillin / clavulanate) for a long time
            • Mononucleosis
            • Using oral birth control pills
            Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            No food related info.
            • Take with food if you're having upset stomach.
            Kidneys and liver
            • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
            • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
            Upsides and benefits
            • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
            • Works well to treat many types of bacterial infections
            • Available as generic product.
            • Available in tablet, capsule, and liquid forms.
            • Used to treat most common types of bacterial infections.
            • Side effects are generally not too bad compared to other antibiotics.
            Downsides and risks
            • Makes you sensitive to the sun.
            • Can upset your stomach
            • Drink plenty of water or fluids to avoid harming your kidneys
            • May cause birth defects
            • Many bacteria have developed resistance to this antibiotic.
            • Can cause diarrhea, nausea, and vomiting.
            • Birth control pills may not work as well to prevent pregnancy when taking this medication.
            Tips from our pharmacists for people taking the medication
            • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
            • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
            • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
            • Can cause upset stomach.
            • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
            • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
            • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
            • Take with food if you're having upset stomach.
            • Store the liquid in the fridge and throw away after 10 days.
            • Shake the suspension thoroughly before using each dose.
            Learn more
            More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Bactrim (sulfamethoxazole / trimethoprim)?
            Worth itNot sureNot worth it
            More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Augmentin (amoxicillin / clavulanate)?
            Worth itNot sureNot worth it