Compare Bactrim vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Bactrim
(Sulfamethoxazole / Trimethoprim)

Augmentin
(Amoxicillin / Clavulanate)

Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.96Bactrim
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
of people (All ages) say Bactrim (Sulfamethoxazole / Trimethoprim) is worth it
49%
say it works well
22%
say it's a big hassle
473 reviews
Have you used Bactrim (Sulfamethoxazole / Trimethoprim)?
Worth itNot sureNot worth it
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
+9% vs. Bactrim (Sulfamethoxazole / Trimethoprim)
52%
+3% vs. Bactrim (Sulfamethoxazole / Trimethoprim)
13%
+9% vs. Bactrim (Sulfamethoxazole / Trimethoprim)
1034 reviews
Have you used Augmentin (Amoxicillin / Clavulanate)?
Worth itNot sureNot worth it
Side effects
BactrimAugmentin

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »
How it works
BactrimAugmentin
Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.
Type of medication
BactrimAugmentin
Antibiotic
Sulfonamide
Prescription only
Antibiotic
Penicillin
Prescription only
Available as
BactrimAugmentin
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for (click to learn more)
BactrimAugmentin
Risk factors for serious side effects
BactrimAugmentin
    Detailed risks & warnings »
    • Mononucleosis
    • History of liver disease
    Detailed risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    BactrimAugmentin
    No food related info.
    • Should be taken with food since it can cause stomach upset.
    • Take each dose with a meal since it may cause an upset stomach.
    Kidneys and liver
    BactrimAugmentin
    No kidneys and liver related info.
    • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
    Upsides and benefits
    BactrimAugmentin
    • Available in different forms: tablet, capsule and suspension.
    • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
    • Available in generic.
    • Used to treat many types of bacterial infections.
    • Available in different forms: tablet, capsule, and suspension.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    • Available in generic.
    • Used to treat many types of bacterial infections.
    Downsides and risks
    BactrimAugmentin
    • Makes your skin more sensitive to the sun.
    • Has to be taken with plenty of liquids.
    • May cause birth defects.
    • Can cause diarrhea.
    • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
    • Should be taken with food since it can cause stomach upset.
    • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
    Tips from our pharmacists for people taking the medication
    BactrimAugmentin
    • Take this medication exactly how your doctor tells you to.
    • Can make your skin more sensitive to the sun.
    • Drink plenty of liquids when taking the medication.
    • Can cause diarrhea, nausea or vomiting.
    • Can cause rash.
    • Take this medication exactly as your doctor tells you to.
    • Take each dose with a meal since it may cause an upset stomach.
    • If you are taking birth control pills, this can make it less effective.
    • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
    Learn more
    More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Bactrim (Sulfamethoxazole / Trimethoprim)?
    Worth itNot sureNot worth it
    More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Augmentin (Amoxicillin / Clavulanate)?
    Worth itNot sureNot worth it