Compare Belsomra vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Belsomra
(suvorexant)

Silenor
(doxepin)

Helps you sleep. Belsomra (suvorexant) helps you fall asleep, but is only avaliable as a brand name so can be expensive.Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Belsomra (suvorexant)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Side effects
BelsomraSilenor
  • Headache 1%
  • Sleepiness 4%
  • Dizziness 1%
  • Diarrhea 1%
  • Dry mouth 1%
  • Cold and flu 1%
  • Abnormal dreams 1%
  • Cough 1%
More Belsomra side effects »

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »
How it works
BelsomraSilenor
Belsomra (suvorexant) is a newer, non-benzodiazepine option that reduces wakefulness and help with sleep by inhibiting the orexin receptors in the brain.Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.
Type of medication
BelsomraSilenor
Prescription only
Available as
BelsomraSilenor
  • Pill
  • Pill
  • Liquid
Used for
BelsomraSilenor
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
BelsomraSilenor
  • Uncontrolled psychiatric conditions
  • Alcohol
  • Other medicines that make you sleepy or dizzy
  • Taking other medicines that make you less alert
Detailed Belsomra (suvorexant) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    BelsomraSilenor
    No interactions related info.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Alcohol
    BelsomraSilenor
    • Not safe to take with alcohol or sleeping medications.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    Sleep
    BelsomraSilenor
    • If you have COPD or sleep apnea, talk to your doctor first about Belsomra (suvorexant) before starting it. Belsomra (suvorexant) can make it hard to breathe.
    • Only take if you plan to sleep at least 7 hours.
    • May be helpful if other sleep aids don't work.
    • Not recommended if you do not plan to sleep for at least 7 hours.
    No sleep related info.
    Weight
    BelsomraSilenor
    No weight related info.
    • Doxepin can increase your appetite, leading to weight gain.
    Upsides and benefits
    BelsomraSilenor
    • May be helpful if other sleep aids don't work.
    • Works quickly, especially on an empty stomach.
    • Might be a good option for the elderly.
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    Downsides and risks
    BelsomraSilenor
    • Not usually used for long-term treatment since it can be habit-forming.
    • Belsomra (suvorexant) is likely expensive since it's only available as a brand name, but coupon savings program could be available.
    • Not recommended if you do not plan to sleep for at least 7 hours.
    • Belsomra (suvorexant) may cause sleep paralysis.
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Tips from our pharmacists for people taking the medication
    BelsomraSilenor
    • Take Belsomra (suvorexant) 30 minutes before bedtime.
    • Only take if you plan to sleep at least 7 hours.
    • Taking Belsomra (suvorexant) on an empty stomach will quicken the effects.
    • Belsomra (suvorexant) can be addictive and is meant for short-term treatment.
    • Can cause headaches and/or dizziness.
    • Not safe to take with alcohol or sleeping medications.
    • If Belsomra (suvorexant) does not help you sleep after taking it for 10 days, consider talking to your doctor/pharmacist about other potential causes of insominia.
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    Learn more
    More about BelsomraSide effectsAlternativesFDA package insert
    Have you used Belsomra (suvorexant)?
    Worth itNot sureNot worth it
    More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it