Compare Benadryl vs. Ambien

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(Diphenhydramine)

Ambien
(Zolpidem)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Helps you sleep. Ambien (Zolpidem) is good for falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause disturbing side effects.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.5767790262172285Benadryl
Reviews for Benadryl (Diphenhydramine)
85%
of people (All ages) say Benadryl (Diphenhydramine) is worth it
57%
say it works well
8%
say it's a big hassle
267 reviews
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
Reviews for Ambien (Zolpidem)
66%
19% vs. Benadryl (Diphenhydramine)
50%
7% vs. Benadryl (Diphenhydramine)
16%
8% vs. Benadryl (Diphenhydramine)
1345 reviews
Have you used Ambien (Zolpidem)?
Worth itNot sureNot worth it
Side effects
BenadrylAmbien

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Dizziness 4%
  • Drowsiness 3%
  • Allergy 3%
  • Sinus inflammation 2%
  • Dry mouth 2%
  • Sore throat 2%
  • Diarrhea 2%
  • Lack of energy 2%
  • Lightheadedness 1%
  • Low mood disorder 1%
More Ambien side effects »
How it works
BenadrylAmbien
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Ambien (Zolpidem) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.
Type of medication
BenadrylAmbien
Antihistamine
1st generation
Prescription or OTC
SedativePrescription only
Available as
BenadrylAmbien
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Extended release
Used for (click to learn more)
BenadrylAmbien
Risk factors for serious side effects
BenadrylAmbien
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs
    • Respiratory conditions
    • Liver problems
    • Muscle disease
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Ambien (Zolpidem) with other nervous system depressants
    • Long-term use
    • Women of childbearing age
    • Breast-feeding
    Detailed Ambien (Zolpidem) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    BenadrylAmbien
    • Don't take it with alcohol or other drugs that make you sleepy.
    • Avoid alcohol and drugs.
    Kidneys and liver
    BenadrylAmbien
    No kidneys and liver related info.
    • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
    Sleep
    BenadrylAmbien
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Effective at helping people fall asleep faster and sleep longer.
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, and dizziness.
    • Ambien (Zolpidem) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Ambien (Zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
    Upsides and benefits
    BenadrylAmbien
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • Effective at helping people fall asleep faster and sleep longer.
    • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
    Downsides and risks
    BenadrylAmbien
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Not typically used for long-term treatment because it can be habit-forming.
    • Some people find that it's less effective over time.
    • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
    • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    Tips from our pharmacists for people taking the medication
    BenadrylAmbien
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Works best if taken without food.
    • Avoid alcohol and drugs.
    • Withdrawal symptoms usually resolve in 1 to 2 nights.
    • Report any confusion or changes in thoughts or behavior.
    Learn more
    More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Benadryl (Diphenhydramine)?
    Worth itNot sureNot worth it
    More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Ambien (Zolpidem)?
    Worth itNot sureNot worth it