Compare Benadryl vs. amoxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(diphenhydramine)

Asendin
(amoxapine)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.
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Prices and coupon for 30 (25mg) capsules of diphenhydramine
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Prices and coupon for 30 (50mg) tablets of amoxapine
Reviews & ratings
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5.63Benadryl
Reviews for Benadryl (diphenhydramine)
86%
of people (All ages) say Benadryl (diphenhydramine) is worth it
59%
say it works well
8%
say it's a big hassle
294 reviews
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Side effects
Benadrylamoxapine

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »
How it works
Benadrylamoxapine
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.
Type of medication
Benadrylamoxapine
Prescription or OTC
Prescription only
Available as
Benadrylamoxapine
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
Used for
Benadrylamoxapine
Risk factors for serious side effects
Benadrylamoxapine
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (diphenhydramine) risks & warnings »
  • People under age 24
  • Glaucoma
    • Taking antidepressants
    • Taking opioids for pain relief or medicines for anxiety
    • Over age 65
    Detailed Asendin (amoxapine) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    Benadrylamoxapine
    • Don't take it with alcohol or other drugs that make you sleepy.
    No alcohol related info.
    Food
    Benadrylamoxapine
    No food related info.
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    Sleep
    Benadrylamoxapine
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    Upsides and benefits
    Benadrylamoxapine
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • Asendin (amoxapine) can be used to treat more severe forms of depression.
    • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
    • Asendin (amoxapine) is available as generic.
    Downsides and risks
    Benadrylamoxapine
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
    • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
    • Not recommended in older people, children under 16, or people who've had a history of seizures.
    Tips from our pharmacists for people taking the medication
    Benadrylamoxapine
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • You might not notice any changes in your mood for at least a few weeks.
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
    • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
    Learn more
    More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Benadryl (diphenhydramine)?
    Worth itNot sureNot worth it
    More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Asendin (amoxapine)?
    Worth itNot sureNot worth it