Compare Benadryl vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl (Diphenhydramine)

Prescription or OTC

Anafranil (Clomipramine)

Prescription only
Treats allergy symptoms and helps you sleep.

Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.

4.1/ 5 average rating with 294 reviewsforBenadryl
Helps with your actions.

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

Upsides
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
Price
No pricing information available
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Reviews
294 reviews so far
86%
saidit'sworth it
59%
saiditworked well
8%
saidit'sa big hassle

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Side effects
The Benadryl (Diphenhydramine) FDA package insert doesn’t have numbers about how common side effects are.
109possible side effects
  • Dry mouth
    84%
  • Somnolence
    54%
  • Tremor
    54%
  • Dizziness
    54%
  • Headache
    52%
  • Constipation
    47%
  • Ejaculation failure
    42%
  • Fatigue
    39%
  • Nausea
    33%
  • Increased sweating
    28%
  • Insomnia
    25%
  • Dyspepsia
    22%
  • Anorexia
    22%
  • Libido change
    21%
  • Any side effect
    20%
  • Impotence
    20%
  • Nervousness
    18%
  • Weight increase
    18%
  • Abnormal vision
    18%
  • Pharyngitis
    14%
  • Micturition disorder
    14%
  • Myoclonus
    13%
  • Diarrhea
    13%
  • Myalgia
    13%
  • Abdominal pain
    13%
  • Rhinitis
    12%
  • Dysmenorrhea
    12%
  • Increased appetite
    11%
  • Digestive system complaints, mainly nausea and vomiting
    10%
  • Paresthesia
    9%
  • Memory impairment
    9%
  • Anxiety
    9%
  • Sleep disorder
    9%
  • Rash
    8%
  • Flushing
    8%
  • Taste perversion
    8%
  • Twitching
    7%
  • Vomiting
    7%
  • Chest pain
    7%
  • Allergy
    7%
  • Weight decrease
    7%
  • Bronchospasm
    7%
  • Urinary retention
    7%
  • Pruritus
    6%
  • Flatulence
    6%
  • Postural hypotension
    6%
  • Sinusitis
    6%
  • Coughing
    6%
  • Urinary tract infection
    6%
  • Tinnitus
    6%
  • Back pain
    6%
  • Nervous system complaints, mainly somnolence
    5%
  • Impaired concentration
    5%
  • Depression
    5%
  • Tooth disorder
    5%
  • Hot flushes
    5%
  • Micturition frequency
    5%
  • Hypertonia
    4%
  • Fever
    4%
  • Palpitation
    4%
  • Tachycardia
    4%
  • Lactation (nonpuerperal)
    4%
  • Menstrual disorder
    4%
  • Pain
    4%
  • Otitis media
    4%
  • Psychosomatic disorder
    3%
  • Yawning
    3%
  • Confusion
    3%
  • Speech disorder
    3%
  • Abnormal dreaming
    3%
  • Agitation
    3%
  • Migraine
    3%
  • Abnormal lacrimation
    3%
  • Arthralgia
    3%
  • Depersonalization
    2%
  • Irritability
    2%
  • Emotional lability
    2%
  • Dermatitis
    2%
  • Acne
    2%
  • Dry skin
    2%
  • Gastrointestinal disorder
    2%
  • Dysphagia
    2%
  • Local edema
    2%
  • Chills
    2%
  • Epistaxis
    2%
  • Dysuria
    2%
  • Cystitis
    2%
  • Vaginitis
    2%
  • Leukorrhea
    2%
  • Breast enlargement
    2%
  • Mydriasis
    2%
  • Thirst
    2%
  • Panic reaction
    2%
  • Aggressive reaction
    2%
  • Paresis
    2%
  • Abnormal skin odor
    2%
  • Eructation
    2%
  • Ulcerative stomatitis
    2%
  • Asthenia
    2%
  • Halitosis
    2%
  • Syncope
    2%
  • Dyspnea
    2%
  • Laryngitis
    2%
  • Anisocoria
    2%
  • Blepharospasm
    2%
  • Ocular allergy
    2%
  • Vestibular disorder
    2%
  • Muscle weakness
    2%
  • Anemia
    2%
See more detailed side effects
Risks and risk factors
  • Overdose
    • Using other drugs with the same ingredients
  • Increased side effects
    • Age 65 years or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Hyperactivity
    • Children age 6 years and younger
  • Trouble urinating
    • Enlarged prostate
    • History of bladder problems
  • Vision changes
    • Glaucoma
  • Breastfeeding
    • Nursing mothers
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Seizure
    • History of seizure
    • Taking other medicines that increase seizure risk
    • Alcoholism
  • Withdrawal
    • Stopping Anafranil (Clomipramine) suddenly
  • Low blood pressure
    • Age 65 years or older
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings