Compare Benadryl vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(Diphenhydramine)

Anafranil
(Clomipramine)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.63Benadryl
Reviews for Benadryl (Diphenhydramine)
86%
of people (All ages) say Benadryl (Diphenhydramine) is worth it
59%
say it works well
8%
say it's a big hassle
294 reviews
Have you used Benadryl (Diphenhydramine)?
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Have you used Anafranil (Clomipramine)?
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Side effects
BenadrylAnafranil

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Drowsiness 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »
How it works
BenadrylAnafranil
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
BenadrylAnafranil
Prescription or OTC
Prescription only
Available as
BenadrylAnafranil
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
Used for
BenadrylAnafranil
Risk factors for serious side effects
BenadrylAnafranil
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
  • Taking other medicines that increase seizure risk
  • Alcoholism
  • Stopping Anafranil (Clomipramine) suddenly
  • Age 65 years or older
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Anafranil (Clomipramine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
BenadrylAnafranil
  • Don't take it with alcohol or other drugs that make you sleepy.
No alcohol related info.
Food
BenadrylAnafranil
No food related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sleep
BenadrylAnafranil
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
Upsides and benefits
BenadrylAnafranil
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides and risks
BenadrylAnafranil
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Tips from our pharmacists for people taking the medication
BenadrylAnafranil
  • Take it as needed every 4 to 6 hours.
  • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (Clomipramine)?
Worth itNot sureNot worth it