Compare Benadryl vs. Atarax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl (Diphenhydramine)

Prescription or OTC
Treats allergy symptoms and helps you sleep.

Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.

5.6/ 7 average rating with 294 reviewsforBenadryl
Relieves anxiety and itching caused by allergic reactions.

Atarax (Hydroxyzine Hydrochloride) is an effective treatment for the itching caused by an allergic reaction. It can also help treat mild anxiety.

5.4/ 7 average rating with 34 reviewsforAtarax
Upsides
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Atarax (Hydroxyzine Hydrochloride) can be used to treat mild cases of anxiety, and for alcohol withdrawal.
  • Can be a better option for some people to treat anxiety than more addicting medications like benzodiazepines.
  • Atarax (Hydroxyzine Hydrochloride) is available as a liquid or as tablets.
  • It can be taken with or without food.
Downsides
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
  • The dose of Atarax (Hydroxyzine Hydrochloride) should be reduced for people who are older or who have reduced liver or kidney function.
  • Atarax (Hydroxyzine Hydrochloride) can cause confusion, dry mouth, constipation, and urinary side effects. These symptoms are worse in older people.
  • As with some medicines, the tablets contain lactose. If you’re lactose intolerant, you could be sensitive to this.
  • Not recommended if you’re pregnant or breastfeeding.
  • Shouldn't take other medicines that cause drowsiness or dizziness.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Liquid
Price
No pricing information available
Lowest price near you
$12.23
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Reviews
294 
86%
think this treatment is worth it
59%
think this treatment works well
8%
think this treatment is a hassle

Have you used Benadryl (Diphenhydramine)?

Leave a review
34 
79%
think this treatment is worth it
68%
think this treatment works well
9%
think this treatment is a hassle

Have you used Atarax (Hydroxyzine Hydrochloride)?

Leave a review
Side effects
The Benadryl (Diphenhydramine) FDA package insert doesn’t have numbers about how common side effects are.
The Atarax (Hydroxyzine Hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Overdose

    Using other drugs with the same ingredients

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Hyperactivity

    Children age 6 years and younger

  • Trouble urinating

    Enlarged prostate

    ...and 1 more risk factors

  • Vision changes

    Glaucoma

  • Breastfeeding

    Nursing mothers

See more detailed risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Risk to fetus

    Women of childbearing age

    ...and 1 more risk factors

  • Increased side effects

    People 65 years or older

    ...and 3 more risk factors

See more detailed risks and warnings