Compare Benadryl vs. Flonase

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(Diphenhydramine)

Flonase
(Fluticasone)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.5767790262172285Benadryl
Reviews for Benadryl (Diphenhydramine)
85%
of people say Benadryl (Diphenhydramine) is worth it
57%
say it works well
8%
say it's a big hassle
Reviews for Flonase (Fluticasone)
72%
13% vs. Benadryl (Diphenhydramine)
43%
14% vs. Benadryl (Diphenhydramine)
7%
+1% vs. Benadryl (Diphenhydramine)
Side effects
BenadrylFlonase

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Asthma symptoms 4%
  • Nausea/vomiting 3%
  • Nosebleed 2%
  • Headache 1%
  • Cough 1%
  • Sore throat 1%
More Flonase side effects »
How it works
BenadrylFlonase
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.
Type of medication
BenadrylFlonase
Antihistamine
1st generation
Prescription or OTC
Anti-inflammatory
Corticosteroid
Prescription or OTC
Available as
BenadrylFlonase
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Nasal spray
Used for (click to learn more)
BenadrylFlonase
Risk factors for serious side effects
BenadrylFlonase
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Taking more than recommended dose
    • Switching from oral or injectable steroids to inhaled, especially if used long term
    • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Exposure to immunizable diseases (chickenpox and measles)
    • Exposure to tuberculosis
    • Surgery or trauma to the nose or sinuses
    • Long-term use
    Detailed Flonase (Fluticasone) risks & warnings »
    Pregnancy category
    BenadrylFlonase
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    • Don't take it with alcohol or other drugs that make you sleepy.
    No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • People age 65 years and older have a higher risk of side effects from taking antihistamine medications like Benadryl (Diphenhydramine). Watch for changes in vision, severe dry mouth, trouble urinating, or constipation. The drowsiness caused by Benadryl (Diphenhydramine) can make you "unsteady" on your feet, leading to a higher chance of falls.
    No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    BenadrylFlonase
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Available as a generic medication.
    Downsides and risks
    BenadrylFlonase
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
    • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    Tips from our pharmacists for people taking the medication
    BenadrylFlonase
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • It can take several days for Flonase (Fluticasone) to start working fully.
    • Don't take more of it than was prescribed for you.
    • Blow your nose before using Flonase (Fluticasone).
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Can also cause a headache, sore throat, or nosebleeds.
    Learn more
    More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
    More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert