Compare Benadryl vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(Diphenhydramine)

Oleptro
(Trazodone)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.5767790262172285Benadryl
Reviews for Benadryl (Diphenhydramine)
85%
of people say Benadryl (Diphenhydramine) is worth it
57%
say it works well
8%
say it's a big hassle
Reviews for Oleptro (Trazodone)
72%
13% vs. Benadryl (Diphenhydramine)
48%
9% vs. Benadryl (Diphenhydramine)
24%
16% vs. Benadryl (Diphenhydramine)
Side effects
BenadrylOleptro

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
BenadrylOleptro
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
BenadrylOleptro
Antihistamine
1st generation
Prescription or OTC
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
BenadrylOleptro
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Extended release
Used for (click to learn more)
BenadrylOleptro
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Benadryl (Diphenhydramine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)
Risk factors for serious side effects
BenadrylOleptro
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (Trazodone) risks & warnings »
    Pregnancy category
    BenadrylOleptro
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    • Don't take it with alcohol or other drugs that make you sleepy.
    No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.
    • Fewer sexual side effects than many other antidepressants.
    • Seek medical attention for unwanted, persistent erection.
    • Rarely, Oleptro (Trazodone) can cause a painful, persistent erection for 4 hours or more. Seek medical attention.
    Sleep
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • People age 65 years and older have a higher risk of side effects from taking antihistamine medications like Benadryl (Diphenhydramine). Watch for changes in vision, severe dry mouth, trouble urinating, or constipation. The drowsiness caused by Benadryl (Diphenhydramine) can make you "unsteady" on your feet, leading to a higher chance of falls.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    BenadrylOleptro
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Fewer sexual side effects than many other antidepressants.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    BenadrylOleptro
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Not as effective as other medications for depression.
    • More sedating than other antidepressants.
    • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    BenadrylOleptro
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • Makes you sleepy. Take at bedtime.
    • Can cause temporary dry mouth and upset stomach.
    • Seek medical attention for unwanted, persistent erection.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
    More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert