Compare Benadryl vs. Prosom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(Diphenhydramine)

Prosom
(Estazolam)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Coming soon.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.5767790262172285Benadryl
Reviews for Benadryl (Diphenhydramine)
85%
of people (All ages) say Benadryl (Diphenhydramine) is worth it
57%
say it works well
8%
say it's a big hassle
267 reviews
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Prosom (Estazolam)?
Worth itNot sureNot worth it
Side effects
BenadrylProsom

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »

We haven’t found good data for Prosom side effects.

FDA side effect reports for Prosom »
How it works
BenadrylProsom
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Coming soon.
Type of medication
BenadrylProsom
Antihistamine
1st generation
Prescription or OTC
Coming soon.
Available as
BenadrylProsom
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
Used for (click to learn more)
BenadrylProsom
  • Insomnia
Risk factors for serious side effects
BenadrylProsom
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
Coming soon.
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
BenadrylProsom
  • Don't take it with alcohol or other drugs that make you sleepy.
No alcohol related info.
Sleep
BenadrylProsom
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
No sleep related info.
Upsides and benefits
BenadrylProsom
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
Coming soon
Downsides and risks
BenadrylProsom
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
Coming soon
Tips from our pharmacists for people taking the medication
BenadrylProsom
  • Take it as needed every 4 to 6 hours.
  • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
Coming soon
Learn more
More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
More about ProsomSide effectsFDA package insert
Have you used Prosom (Estazolam)?
Worth itNot sureNot worth it