Compare Benadryl vs. Estazolam

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl (Diphenhydramine)

Prescription or OTC

Prosom (estazolam)

Prescription only
Treats allergy symptoms and helps you sleep.

Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.

5.6/ 7 average rating with 294 reviewsforBenadryl
Helps you stay asleep longer.

Prosom (estazolam) can help you sleep, but you might feel hungover the next day.

Upsides
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Prosom (estazolam) is available in generic.
Downsides
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
  • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
  • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
  • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
No pricing information available
No pricing information available
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Reviews
294 
86%
think this treatment is worth it
59%
think this treatment works well
8%
think this treatment is a hassle

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Side effects
The Benadryl (Diphenhydramine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Sleepiness
    42%
  • Headache
    16%
  • Weakness
    11%
  • Difficulty controlling muscles
    8%
  • Nervousness
    8%
  • Dizziness
    7%
  • Uneasiness
    5%
  • Nausea
    4%
  • Abnormal coordination
    4%
  • Leg and foot pain
    3%
See more detailed side effects
Risks and warnings
  • Overdose

    Using other drugs with the same ingredients

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Hyperactivity

    Children age 6 years and younger

  • Trouble urinating

    Enlarged prostate

    ...and 1 more risk factors

  • Vision changes

    Glaucoma

  • Breastfeeding

    Nursing mothers

See more detailed risks and warnings
  • Tolerance and addiction

    Using Prosom (estazolam) for more than 10 days

  • Behavior changes

    Drinking alcohol

    ...and 1 more risk factors

  • Hangover effect

    People age 65 or older

See more detailed risks and warnings