Compare Benadryl vs. Estazolam

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(diphenhydramine)

Prosom
(estazolam)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Helps you stay asleep longer. Prosom (estazolam) can help you sleep, but you might feel hungover the next day.
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Prices and coupon for 30 (25mg) capsules of diphenhydramine
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Prices and coupon for 30 (2mg) tablets of estazolam
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.63Benadryl
Reviews for Benadryl (diphenhydramine)
86%
of people (All ages) say Benadryl (diphenhydramine) is worth it
59%
say it works well
8%
say it's a big hassle
294 reviews
Have you used Benadryl (diphenhydramine)?
Worth itNot sureNot worth it

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Have you used Prosom (estazolam)?
Worth itNot sureNot worth it
Side effects
BenadrylEstazolam

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »
  • Sleepiness 15%
  • Weakness 3%
  • Difficulty controlling muscles 4%
  • Dizziness 4%
  • Abnormal coordination 3%
  • Leg and foot pain 1%
More Estazolam side effects »
How it works
BenadrylEstazolam
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Prosom (estazolam) is a benzodiazepine. It helps you stay asleep by improving the quality of your sleep so you don't wake up as much at night.
Type of medication
BenadrylEstazolam
Prescription or OTC
Prescription only
Available as
BenadrylEstazolam
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
Used for
BenadrylEstazolam
Risk factors for serious side effects
BenadrylEstazolam
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (diphenhydramine) risks & warnings »
  • Using Prosom (estazolam) for more than 10 days
  • Drinking alcohol
  • Taking sedative medicines
  • People age 65 or older
    Detailed Prosom (estazolam) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    BenadrylEstazolam
    • Don't take it with alcohol or other drugs that make you sleepy.
    • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
    Sleep
    BenadrylEstazolam
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    No sleep related info.
    Upsides and benefits
    BenadrylEstazolam
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • Prosom (estazolam) is available in generic.
    Downsides and risks
    BenadrylEstazolam
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
    • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
    • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
    Tips from our pharmacists for people taking the medication
    BenadrylEstazolam
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • Don't take Prosom (estazolam) unless you know you'll be going to sleep right away.
    • Make sure you can sleep for at least 8 hours before you take it.
    • Prosom (estazolam) works best if you develop good sleeping habits.
    • Take Prosom (estazolam) for the shortest amount of time needed to treat your insomnia since it can be addicting.
    • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
    Learn more
    More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Benadryl (diphenhydramine)?
    Worth itNot sureNot worth it
    More about EstazolamSide effectsAlternativesFDA package insert
    Have you used Prosom (estazolam)?
    Worth itNot sureNot worth it