Compare Benadryl vs. Restoril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benadryl
(Diphenhydramine)

Restoril
(Temazepam)

Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Helps you relax and sleep. Restoril (Temazepam) is a good short-term option to help you sleep, but it shouldn't replace good sleep habits.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.5767790262172285Benadryl
Reviews for Benadryl (Diphenhydramine)
85%
of people say Benadryl (Diphenhydramine) is worth it
57%
say it works well
8%
say it's a big hassle
Reviews for Restoril (Temazepam)
56%
29% vs. Benadryl (Diphenhydramine)
56%
1% vs. Benadryl (Diphenhydramine)
22%
14% vs. Benadryl (Diphenhydramine)
Side effects
BenadrylRestoril

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »

We haven’t found good data for Restoril side effects.

FDA side effect reports for Restoril »
How it works
BenadrylRestoril
Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Restoril (Temazepam) is a benzodiazepine. It affects chemicals in the brain to calm down your nervous system, helping you sleep and be less anxious.
Type of medication
BenadrylRestoril
Antihistamine
1st generation
Prescription or OTC
Anti-anxiety
Benzodiazepine
Prescription only
Available as
BenadrylRestoril
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
Used for (click to learn more)
BenadrylRestoril
Risk factors for serious side effects
BenadrylRestoril
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Women of childbearing age
  • Alcohol
  • Taking other medicines that make you less alert
    • Taking with alcohol
    • Taking with other drugs that acts in the brain
    • Age 65 or older
    Detailed Restoril (Temazepam) risks & warnings »
    Pregnancy category
    BenadrylRestoril
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    Alcohol
    • Don't take it with alcohol or other drugs that make you sleepy.
    • It is not safe to drink alcohol while taking this.
    • Restoril (Temazepam) can make you dizzy and drowsy, especially when combined with alcohol and many other medicines that acts in your brain. It is not recommended for people age 65 years or older.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • People age 65 years and older have a higher risk of side effects from taking antihistamine medications like Benadryl (Diphenhydramine). Watch for changes in vision, severe dry mouth, trouble urinating, or constipation. The drowsiness caused by Benadryl (Diphenhydramine) can make you "unsteady" on your feet, leading to a higher chance of falls.
    • Can be habit-forming, meaning you'll start to rely on Restoril (Temazepam) to sleep.
    • Shouldn't make you drowsy the next day as long as you're using normal doses of it.
    • Use only as needed when you can't sleep.
    • Can cause dizziness and drowsiness, so don't do anything (like driving) after taking it that requires you to focus.
    • Stopping Restoril (Temazepam) suddenly can cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and muscle pain or burning. Withdrawal symptoms can last 6 weeks or longer. Work with your doctor to gradually reduce your dose.
    • Restoril (Temazepam) can make you dizzy and drowsy, especially when combined with alcohol and many other medicines that acts in your brain. It is not recommended for people age 65 years or older.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    BenadrylRestoril
    • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It makes you sleepy, so it'll help if your allergies are bothering you at night.
    • The effects wear off in 4 to 6 hours, so side effects don't last that long.
    • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
    • Helps you fall asleep and stay asleep.
    • Can be helpful to reduce anxiety.
    • Shouldn't make you drowsy the next day as long as you're using normal doses of it.
    Downsides and risks
    BenadrylRestoril
    • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
    • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
    • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
    • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
    • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
    • Can be habit-forming, meaning you'll start to rely on Restoril (Temazepam) to sleep.
    • Your body can get used to Restoril (Temazepam) and it may not work as well long-term.
    • It's not recommended for people age 65 years or older.
    • Can't be used by pregnant women since it'll cause harm to the baby.
    • If it's used everyday for more than 2 to 4 weeks and you decide to stop taking Restoril (Temazepam), you'll need to work with your doctor to slowly get off the drug to avoid extra side effects.
    Tips from our pharmacists for people taking the medication
    BenadrylRestoril
    • Take it as needed every 4 to 6 hours.
    • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
    • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
    • Use only as needed when you can't sleep.
    • Starts working within 45 minutes.
    • Can cause dizziness and drowsiness, so don't do anything (like driving) after taking it that requires you to focus.
    • Take it only if you can get a full night's rest.
    • It is not safe to drink alcohol while taking this.
    • Tell your doctor if you notice any changes to your memory or mood.
    Learn more
    More about BenadrylSide effectsReviews & ratingsAlternativesFDA package insert
    More about RestorilSide effectsReviews & ratingsAlternativesFDA package insert