Compare benazepril vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lotensin
(benazepril)

Microzide
(hydrochlorothiazide )

Lowers blood pressure. Lotensin (benazepril) is a good blood pressure-lowering medicine that also protects kidney function.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Coupons for benazepril
Best available price for 30 (20mg) tablets of benazepril
Best available price for 30 (12.5mg) capsules of hydrochlorothiazide
Reviews & ratings
Filter group. All currently selected
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5.45benazepril
Reviews for benazepril
61%
of people (All ages) say benazepril is worth it
64%
say it works well
23%
say it's a big hassle
Have you used Lotensin (benazepril)?
Worth itNot sureNot worth it
Reviews for hydrochlorothiazide
47%
+14% better vs. benazepril
31%
+33% better vs. benazepril
16%
-7% worse vs. benazepril
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
benazeprilhydrochlorothiazide
  • Headache 2%
  • Dizziness 2%
  • Drowsiness 2%
  • Dizziness when standing up 2%
More benazepril side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
benazeprilhydrochlorothiazide
Lotensin (benazepril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
benazeprilhydrochlorothiazide
Prescription onlyPrescription only
Available as
benazeprilhydrochlorothiazide
  • Pill
  • Pill
Used for
benazeprilhydrochlorothiazide
Risk factors for serious side effects
benazeprilhydrochlorothiazide
  • Women of childbearing age
  • Infants less than one year old
  • African descent
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
Detailed Lotensin (benazepril) risks & warnings »
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
benazeprilhydrochlorothiazide
  • This drug interacts with other medications that affect potassium, so it needs to be dosed carefully.
No interactions related info.
Kidneys and liver
benazeprilhydrochlorothiazide
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
Upsides and benefits
benazeprilhydrochlorothiazide
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides and risks
benazeprilhydrochlorothiazide
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a regular blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • This drug interacts with other medications that affect potassium, so it needs to be dosed carefully.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Tips from our pharmacists for people taking the medication
benazeprilhydrochlorothiazide
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it doesn't get better.
  • Tell your doctor about any tiredness, cough, mouth swelling, or throat irritation that doesn't go away.
  • Requires blood tests to check potassium levels and kidney function.
  • Don't take it if you're pregnant.
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
Learn more
More about benazeprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lotensin (benazepril)?
Worth itNot sureNot worth it
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it