Compare Benemid vs. Colcrys

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benemid
(probenecid)

Colcrys
(colchicine)

Lowers uric acid levels and strengthens penicillin's effect. Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.
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Prices and coupon for 60 (500mg) tablets of probenecid
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Prices and coupon for 30 (0.6mg) capsules of colchicine
Reviews & ratings
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Have you used Benemid (probenecid)?
Worth itNot sureNot worth it

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Have you used Colcrys (colchicine)?
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Side effects
BenemidColcrys

The Benemid FDA package insert doesn’t have numbers about how common side effects are.

More about Benemid side effects »
  • Stomach problems 6%
  • Diarrhea 9%
  • Gout 2%
  • Throat pain 3%
More Colcrys side effects »
How it works
BenemidColcrys
Benemid (probenecid) stops the kidneys from saving uric acid, so more uric acid leaves the body when you urinate. It also helps antibiotics like penicillin last longer in the body since it stops penicillin from going into the urine.Colcrys (colchicine) stops the redness and swelling in gout attacks by blocking the cells that cause inflammation from going to the affected joints.
Type of medication
BenemidColcrys
Prescription only
Prescription only
Available as
BenemidColcrys
  • Pill
  • Pill
Used for
BenemidColcrys
Risk factors for serious side effects
BenemidColcrys
    • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
    • Taking Benemid (probenecid) for the first few weeks
    • History of kidney problems
    • History of esophagus or stomach problems, including ulcers
    Detailed Benemid (probenecid) risks & warnings »
        • Grapefruit
        • Grapefruit juice
        • Protease inhibitors
        • Antifungal antibiotics
        • Calcium channel blockers
        • Cyclosporine
        • Anti-cholesterol medicines
        • Digoxin
        • Kidney problems
        • Elderly
        • Use of statins or cholesterol medications
        • Use of cyclosporine
        Detailed Colcrys (colchicine) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        BenemidColcrys
        No interactions related info.
        • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
        Food
        BenemidColcrys
        • Take Benemid (probenecid) with food or antacids to minimize stomach side effects.
        • Benemid (probenecid) can irritate your stomach or esophagus, and worsen ulcers. However, this is rare. Take Benemid (probenecid) with food to help stop this from happening. If you get chest pain or stomach pain, or worsening heartburn while taking Benemid (probenecid), talk with your doctor.
        • Take Colcrys (colchicine) with or without food.
        • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
        Kidneys and liver
        BenemidColcrys
        • Benemid (probenecid) can cause kidney stones. Make sure to drink at least eight 8-ounce glasses of water a day while taking Benemid (probenecid). Let your doctor know if you start having back pain, belly pain, or blood in your urine as these may be signs of a kidney stone.
        • Doses needs to be changed if you have kidney or liver problems.
        • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
        Upsides and benefits
        BenemidColcrys
        • Benemid (probenecid) is available in generic.
        • It can raise levels of certain antibiotics in the body and make those antibiotics work better.
        • It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
        • Colcrys (colchicine) treats and stops sudden gout attacks.
        • It can be used to prevent gout when people are first starting on allopurinol.
        • Colcrys (colchicine) also treats Familial Mediterranean fever.
        Downsides and risks
        BenemidColcrys
        • Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
        • It doesn't work well in people who are using aspirin, or have kidney problems.
        • You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
        • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
        • Taking Colcrys (colchicine) for too long can cause problems with your blood.
        • Doses needs to be changed if you have kidney or liver problems.
        • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
        • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
        • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
        Tips from our pharmacists for people taking the medication
        BenemidColcrys
        • Take Benemid (probenecid) with food or antacids to minimize stomach side effects.
        • Benemid (probenecid) doesn't work as well in people with kidney problems or the elderly.
        • Don't take aspirin while taking Benemid (probenecid).
        • Drink plenty of water while on Benemid (probenecid).
        • Take Colcrys (colchicine) with or without food.
        • At the first sign of a gout attack, take 2 tablets. Don't take more than 3 tablets a day in order to avoid serious side effects.
        • Wait at least 3 days before using Colcrys (colchicine) again, or at least 12 hours if you had been using Colcrys (colchicine) prophylactically.
        • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (colchicine).
        • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
        • Avoid grapefruit and grapefruit juice while taking Colcrys (colchicine).
        Learn more
        More about BenemidSide effectsAlternativesFDA package insert
        Have you used Benemid (probenecid)?
        Worth itNot sureNot worth it
        More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Colcrys (colchicine)?
        Worth itNot sureNot worth it