Compare Benemid vs. Colcrys

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benemid (probenecid)

Prescription only

Colcrys (colchicine)

Prescription only
Lowers uric acid levels and strengthens penicillin's effect.

Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.

Prevents and treats gout.

Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.

Upsides
  • Benemid (probenecid) is available in generic.
  • It can raise levels of certain antibiotics in the body and make those antibiotics work better.
  • It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
Downsides
  • Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
  • It doesn't work well in people who are using aspirin, or have kidney problems.
  • You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
Used for
Dosage forms
  • Pill
  • Pill
Price
No pricing information available
Lowest price near you
$190.5
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Reviews
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Side effects
The Benemid (probenecid) FDA package insert doesn’t have numbers about how common side effects are.
The Colcrys (colchicine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Blood disorders

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency

  • Gout attacks

    Taking Benemid (probenecid) for the first few weeks

  • Kidney problems

    History of kidney problems

  • Stomach ulcers

    History of esophagus or stomach problems, including ulcers

See more detailed risks and warnings
  • Food and medicine interactions

    Grapefruit

    ...and 7 more risk factors

  • Muscle pain and breakdown

    Kidney problems

    ...and 3 more risk factors

See more detailed risks and warnings