Compare Benzamycin vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benzamycin
(Benzoyl Peroxide / Erythromycin)

Cleocin T
(Clindamycin Phosphate)

Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.527397260273973Benzamycin
Reviews for Benzamycin (Benzoyl Peroxide / Erythromycin)
54%
of people say Benzamycin (Benzoyl Peroxide / Erythromycin) is worth it
26%
say it works well
12%
say it's a big hassle
Reviews for Cleocin T (Clindamycin Phosphate)
57%
+3% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
43%
+17% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
20%
8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
Side effects
BenzamycinCleocin

The Benzamycin FDA package insert doesn’t have numbers about how common side effects are.

More about Benzamycin side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »
How it works
BenzamycinCleocin
Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
BenzamycinCleocin
Acne agent
Antibiotic
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
BenzamycinCleocin
  • Cream, gel, or ointment
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for (click to learn more)
BenzamycinCleocin
Risk factors for serious side effects
BenzamycinCleocin
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
      Detailed Benzamycin (Benzoyl Peroxide / Erythromycin) risks & warnings »
        • History of liver disease
          Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
          Pregnancy category
          BenzamycinCleocin
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • Can be taken with or without food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          No specific weight-related info.
          Upsides and benefits
          BenzamycinCleocin
          • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
          • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
          • Although Benzamycin can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          • Available in generic.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          Downsides and risks
          BenzamycinCleocin
          • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          • Can cause bleaching of hair and clothing.
          • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          Tips from our pharmacists for people taking the medication
          BenzamycinCleocin
          • Combination medicine you apply to your skin to treat acne.
          • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
          • Store in the refrigerator, but don't freeze.
          • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Learn more
          More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert