Compare Benzamycin vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benzamycin
(Benzoyl Peroxide / Erythromycin)

Akne-Mycin
(Erythromycin)

Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.527397260273973Benzamycin
Reviews for Benzamycin (Benzoyl Peroxide / Erythromycin)
54%
of people say Benzamycin (Benzoyl Peroxide / Erythromycin) is worth it
26%
say it works well
12%
say it's a big hassle
Reviews for Akne-Mycin (Erythromycin)
46%
8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
34%
+8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
20%
8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
Side effects
BenzamycinErygel

The Benzamycin FDA package insert doesn’t have numbers about how common side effects are.

More about Benzamycin side effects »

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »
How it works
BenzamycinErygel
Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
BenzamycinErygel
Acne agent
Antibiotic
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
BenzamycinErygel
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Topical solution
Used for (click to learn more)
BenzamycinErygel
Risk factors for serious side effects
BenzamycinErygel
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
      Detailed Benzamycin (Benzoyl Peroxide / Erythromycin) risks & warnings »
        • Using other medicines or products that irritate the skin
        • Eczema
        • Extreme temperatures (hot or cold)
          Detailed Akne-Mycin (Erythromycin) risks & warnings »
          Pregnancy category
          BenzamycinErygel
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          No specific weight-related info.
          Upsides and benefits
          BenzamycinErygel
          • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
          • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
          • Although Benzamycin can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
          • Available in a gel formulation which may be better if your skin is very oily.
          • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
          Downsides and risks
          BenzamycinErygel
          • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          • Can cause bleaching of hair and clothing.
          • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
          • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          Tips from our pharmacists for people taking the medication
          BenzamycinErygel
          • Combination medicine you apply to your skin to treat acne.
          • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
          • Store in the refrigerator, but don't freeze.
          • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          • Very commonly used topical antibiotic to treat acne.
          • The only topical erythromycin in a gel formula.
          • Apply a thin film to clean and dry affected skin once or twice a day.
          • It may take 6-8 weeks before you see improvement in your acne.
          • Avoid getting into your eyes, nose or mouth.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          Learn more
          More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert
          More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert