Compare Benzoyl Peroxide vs. Benzamycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benzac
(benzoyl peroxide)

Benzamycin
(benzoyl peroxide / erythromycin)

Topical treatment for acne and skin wounds. Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..
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Reviews & ratings
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4.58Benzoyl Peroxide
Reviews for Benzac (benzoyl peroxide)
60%
of people (All ages) say Benzac (benzoyl peroxide) is worth it
29%
say it works well
9%
say it's a big hassle
394 reviews
Have you used Benzac (benzoyl peroxide)?
Worth itNot sureNot worth it
Reviews for Benzamycin (benzoyl peroxide / erythromycin)
54%
-6% worse vs. Benzac (benzoyl peroxide)
26%
-3% worse vs. Benzac (benzoyl peroxide)
12%
-3% worse vs. Benzac (benzoyl peroxide)
146 reviews
Have you used Benzamycin (benzoyl peroxide / erythromycin)?
Worth itNot sureNot worth it
Side effects
Benzoyl PeroxideBenzamycin

The Benzoyl Peroxide FDA package insert doesn’t have numbers about how common side effects are.

More about Benzoyl Peroxide side effects »
  • Dyness 3%
  • Urticarial reaction 3%
More Benzamycin side effects »
How it works
Benzoyl PeroxideBenzamycin
Benzac (Benzoyl Peroxide) is a topical acne medicine. It seems to fight the bacteria responsible for producing acne in oil (sebaceous) glands, and dries out acne-affected areas. Also, it speeds up growth of damaged skin from serious breakdown, injury, or disease.Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.
Type of medication
Benzoyl PeroxideBenzamycin
Prescription or OTC
Prescription only
Available as
Benzoyl PeroxideBenzamycin
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Cream, gel, or ointment
Used for
Benzoyl PeroxideBenzamycin
Risk factors for serious side effects
Benzoyl PeroxideBenzamycin
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      Detailed Benzac (benzoyl peroxide) risks & warnings »
        • Using other medicines or products that irritate the skin
        • Eczema
        • Extreme temperatures (hot or cold)
          • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
          Detailed Benzamycin (benzoyl peroxide / erythromycin) risks & warnings »
          Pregnancy

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Pain
          Benzoyl PeroxideBenzamycin
          No pain related info.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          Weight
          Benzoyl PeroxideBenzamycin
          • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          Upsides and benefits
          Benzoyl PeroxideBenzamycin
          • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
          • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
          • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
          • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
          • Although Benzamycin can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          Downsides and risks
          Benzoyl PeroxideBenzamycin
          • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
          • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
          • Can cause bleaching of hair and clothing.
          • May not work as well when used by itself over long period of time.
          • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
          • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          • Can cause bleaching of hair and clothing.
          • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
          Tips from our pharmacists for people taking the medication
          Benzoyl PeroxideBenzamycin
          • Acne can take several weeks to show up in the skin so it's best to use for 2-3 months before you decide it doesn't work.
          • Studies showed it didn't matter what strength people used, they all took about the same time to work.
          • Higher strengths greater than 2.5% may not work any better but might cause more side effects.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          • Combination medicine you apply to your skin to treat acne.
          • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
          • Store in the refrigerator, but don't freeze.
          • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          Learn more
          More about Benzoyl PeroxideSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Benzac (benzoyl peroxide)?
          Worth itNot sureNot worth it
          More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Benzamycin (benzoyl peroxide / erythromycin)?
          Worth itNot sureNot worth it