Compare Benzoyl Peroxide vs. Epiduo

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benzac
(Benzoyl Peroxide)

Epiduo
(Adapalene / Benzoyl Peroxide)

Topical treatment for acne and skin wounds. Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.Coming soon.
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Reviews & ratings
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4.57544757033248Benzoyl Peroxide
Reviews for Benzac (Benzoyl Peroxide)
60%
of people (All ages) say Benzac (Benzoyl Peroxide) is worth it
29%
say it works well
9%
say it's a big hassle
391 reviews
Have you used Benzac (Benzoyl Peroxide)?
Worth itNot sureNot worth it

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Have you used Epiduo (Adapalene / Benzoyl Peroxide)?
Worth itNot sureNot worth it
Side effects
Benzoyl PeroxideEpiduo

The Benzoyl Peroxide FDA package insert doesn’t have numbers about how common side effects are.

More about Benzoyl Peroxide side effects »

We haven’t found good data for Epiduo side effects.

FDA side effect reports for Epiduo »
How it works
Benzoyl PeroxideEpiduo
Benzac (Benzoyl Peroxide) is a topical acne medicine. It seems to fight the bacteria responsible for producing acne in oil (sebaceous) glands, and dries out acne-affected areas. Also, it speeds up growth of damaged skin from serious breakdown, injury, or disease.Coming soon.
Type of medication
Benzoyl PeroxideEpiduo
Acne agent
Antibiotic
Prescription or OTC
Coming soon.
Available as
Benzoyl PeroxideEpiduo
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Cream, gel, or ointment
Used for (click to learn more)
Benzoyl PeroxideEpiduo
  • Acne vulgaris
Risk factors for serious side effects
Benzoyl PeroxideEpiduo
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      Detailed Benzac (Benzoyl Peroxide) risks & warnings »
      Coming soon.
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Weight
      Benzoyl PeroxideEpiduo
      • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
      No weight related info.
      Upsides and benefits
      Benzoyl PeroxideEpiduo
      • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
      • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
      • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
      • Can be used in combination with acne pill medicine if your doctor thinks you need it.
      • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
      Coming soon
      Downsides and risks
      Benzoyl PeroxideEpiduo
      • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
      • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
      • Can cause bleaching of hair and clothing.
      • May not work as well when used by itself over long period of time.
      • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
      Coming soon
      Tips from our pharmacists for people taking the medication
      Benzoyl PeroxideEpiduo
      • Acne can take several weeks to show up in the skin so it's best to use for 2-3 months before you decide it doesn't work.
      • Studies showed it didn't matter what strength people used, they all took about the same time to work.
      • Higher strengths greater than 2.5% may not work any better but might cause more side effects.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      Coming soon
      Learn more
      More about Benzoyl PeroxideSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Benzac (Benzoyl Peroxide)?
      Worth itNot sureNot worth it
      More about EpiduoSide effectsReviews & ratingsFDA package insert
      Have you used Epiduo (Adapalene / Benzoyl Peroxide)?
      Worth itNot sureNot worth it