Compare Benzoyl Peroxide vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benzac (Benzoyl Peroxide)

Prescription or OTC

Akne-Mycin (Erythromycin)

Prescription only
Topical treatment for acne and skin wounds.

Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.

3.4/ 5 average rating with 394 reviewsforBenzoyl Peroxide
Topical treatment for acne.

Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.

3.4/ 5 average rating with 93 reviewsforErygel
Upsides
  • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
  • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
  • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
  • Can be used in combination with acne pill medicine if your doctor thinks you need it.
  • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
  • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
  • Available in a gel formulation which may be better if your skin is very oily.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
Downsides
  • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
  • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
  • Can cause bleaching of hair and clothing.
  • May not work as well when used by itself over long period of time.
  • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
  • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
  • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
Used for
Dosage forms
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Cream, gel, or ointment
  • Topical solution
Price
No pricing information available
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Reviews
394 reviews so far
60%
saidit'sworth it
29%
saiditworked well
9%
saidit'sa big hassle

Have you used Benzac (Benzoyl Peroxide)?

Leave a review
93 reviews so far
46%
saidit'sworth it
34%
saiditworked well
19%
saidit'sa big hassle

Have you used Akne-Mycin (Erythromycin)?

Leave a review
Side effects
The Benzac (Benzoyl Peroxide) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Burning
    25%
See more detailed side effects
Risks and risk factors
  • Bleaching effects
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Allergic reaction
See more detailed risks and warnings
  • Allergic reaction
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Development of more serious infections
See more detailed risks and warnings