Compare Benzoyl peroxide vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Benzoyl Peroxide)


Topical treatment for acne and skin wounds. Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
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4.57544757033248Benzoyl peroxide
Reviews for Benzac (Benzoyl Peroxide)
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391 reviews
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Side effects
Benzoyl peroxideMinocycline

The Benzoyl peroxide FDA package insert doesn’t have numbers about how common side effects are.

More about Benzoyl peroxide side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
Benzoyl peroxideMinocycline
Benzac (Benzoyl Peroxide) is a topical acne medicine. It seems to fight the bacteria responsible for producing acne in oil (sebaceous) glands, and dries out acne-affected areas. Also, it speeds up growth of damaged skin from serious breakdown, injury, or disease.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Benzoyl peroxideMinocycline
Acne agent
Prescription or OTC
Prescription only
Available as
Benzoyl peroxideMinocycline
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Pill
  • Extended release
  • Extended release capsule
Used for (click to learn more)
Benzoyl peroxideMinocycline
Risk factors for serious side effects
Benzoyl peroxideMinocycline
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      Detailed Benzac (Benzoyl Peroxide) risks & warnings »
      • Age 8 years or younger
      • Using oral birth control pills
      • Long antibiotic treatment period
          • Women of childbearing age
          Detailed Solodyn (Minocycline) risks & warnings »
          Pregnancy category
          Benzoyl peroxideMinocycline
          No specific food related info.
          Upsides and benefits
          Benzoyl peroxideMinocycline
          • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
          • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
          • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
          • Available as a generic, so it should be reasonably priced.
          • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
          • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
          Downsides and risks
          Benzoyl peroxideMinocycline
          • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
          • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
          • Can cause bleaching of hair and clothing.
          • May not work as well when used by itself over long period of time.
          • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
          • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
          • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
          Tips from our pharmacists for people taking the medication
          Benzoyl peroxideMinocycline
          • Acne can take several weeks to show up in the skin so it's best to use for 2-3 months before you decide it doesn't work.
          • Studies showed it didn't matter what strength people used, they all took about the same time to work.
          • Higher strengths greater than 2.5% may not work any better but might cause more side effects.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
          • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
          • Can stain your teeth, tongue and gums, but this is temporary.
          • Take this exactly how your doctor or pharmacist tells you until it's all gone.
          • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
          Learn more
          More about Benzoyl peroxideSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Benzac (Benzoyl Peroxide)?
          Worth itNot sureNot worth it
          More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Solodyn (Minocycline)?
          Worth itNot sureNot worth it