Compare Benzoyl peroxide vs. Minocycline

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(Benzoyl Peroxide)


Topical treatment for acne and skin wounds. Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
How it works
Benzac (Benzoyl Peroxide) is a topical acne medicine. It seems to fight the bacteria responsible for producing acne in oil (sebaceous) glands, and dries out acne-affected areas. Also, it speeds up growth of damaged skin from serious breakdown, injury, or disease.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Acne agent
Prescription or OTC
Prescription only
Available as
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Pill
  • Extended release
  • Extended release capsule
Used for (click to learn more)
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Reviews & ratings
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4.57544757033248Benzoyl peroxide
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Side effects

The Benzoyl peroxide FDA package insert doesn’t have numbers about how common side effects are.

More about Benzoyl peroxide side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
Risk factors for serious side effects
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      Detailed Benzac (Benzoyl Peroxide) risks & warnings »
      • Age 8 years or younger
      • Using oral birth control pills
      • Long antibiotic treatment period
          • Women of childbearing age
          Detailed Solodyn (Minocycline) risks & warnings »
          Pregnancy category
          NFDA pregnancy category (Unknown)

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          See the FDA package insert
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          No specific alcohol-related info.No specific alcohol-related info.
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.No specific sleep-related info.
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
          • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
          • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
          • Available as a generic, so it should be reasonably priced.
          • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
          • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
          Downsides and risks
          • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
          • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
          • Can cause bleaching of hair and clothing.
          • May not work as well when used by itself over long period of time.
          • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
          • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
          • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
          Tips from our pharmacists for people taking the medication
          • Acne can take several weeks to show up in the skin so it's best to use for 2-3 months before you decide it doesn't work.
          • Studies showed it didn't matter what strength people used, they all took about the same time to work.
          • Higher strengths greater than 2.5% may not work any better but might cause more side effects.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
          • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
          • Can stain your teeth, tongue and gums, but this is temporary.
          • Take this exactly how your doctor or pharmacist tells you until it's all gone.
          • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
          Learn more
          More about Benzoyl peroxideSide effectsReviews & ratingsAlternativesFDA package insert
          More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert