Compare Benzoyl Peroxide vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Benzac (Benzoyl Peroxide)

Prescription or OTC

Solodyn (Minocycline)

Prescription only
Topical treatment for acne and skin wounds.

Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.

4.6/ 7 average rating with 394 reviewsforBenzoyl Peroxide
Treats bacterial infections.

Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.

5.5/ 7 average rating with 17 reviewsforMinocycline
Upsides
  • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
  • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
  • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
  • Can be used in combination with acne pill medicine if your doctor thinks you need it.
  • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides
  • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
  • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
  • Can cause bleaching of hair and clothing.
  • May not work as well when used by itself over long period of time.
  • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Used for
Dosage forms
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Pill
  • Extended release
  • Extended release capsule
Price
No pricing information available
Lowest price near you
$98.31
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Reviews
394 
60%
think this treatment is worth it
29%
think this treatment works well
9%
think this treatment is a hassle

Have you used Benzac (Benzoyl Peroxide)?

Leave a review
17 
53%
think this treatment is worth it
59%
think this treatment works well
18%
think this treatment is a hassle

Have you used Solodyn (Minocycline)?

Leave a review
Side effects
The Benzac (Benzoyl Peroxide) FDA package insert doesn’t have numbers about how common side effects are.
The Solodyn (Minocycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Skin irritation

    Using other medicines or products that irritate the skin

    ...and 2 more risk factors

See more detailed risks and warnings
  • Changes in teeth

    Age 8 years or younger

  • Decreased effectiveness of birth control pills

    Using oral birth control pills

  • Diarrhea from a superinfection (an infection that happens after, or in addition to, an earlier infection)

    Long antibiotic treatment period

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings