Compare Betaseron vs. Aubagio

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Betaseron (Interferon Beta-1B)

Prescription only

Aubagio (Teriflunomide)

Prescription only
Lowers the frequency of MS exacerbations.

Betaseron (Interferon Beta-1B) is an injectable medicine effective for relapsing, remitting MS with fewer side effects and every other day dosing.

4.8/ 7 average rating with 21 reviewsforBetaseron
Treats relapsing forms of MS.

Aubagio (Teriflunomide) is an oral medicine that effectively reduces the number of flare-ups, slows physical changes, and decreases the number of new brain lesions in relapsing MS. Because it stays in the body for so long, if you have a serious reaction or possible pregnancy you'll need to have it quickly removed with another medicine.

3.3/ 7 average rating with 23 reviewsforAubagio
  • Interferon beta-1b was the first disease modifying agent for MS approved by the FDA to treat relapsing-remitting multiple sclerosis (RRMS).
  • In short and long-term follow-up studies, Interferon beta-1b was shown to slow MS progression, reduce the number of flair-ups and increase overall survival.
  • Convenient every-other-day dosing and refrigeration-free storage (before mixing) is less of a hassle.
  • Interferon beta-1b has been shown to be more effective than Avonex in reducing new lesions, which lowers relapse and disease progression in people with RRMS.
  • May be a treatment option for people with secondary progressive multiple sclerosis (SPMS).
  • You can take it by mouth.
  • It comes a 7 mg and 14mg dose and only needs to be taken once a day, with or without food.
  • In clinical studies, Aubagio reduced relapses, slowed disability, and decreased the number of new brain lesions compared to sugar pill (placebo).
  • Although it may not work for everyone, most people felt it wasn't much of a hassle.
  • Requires injections.
  • Injection site reactions are common. Symptoms range from pain, redness, and swelling to severe reactions with skin death around the injection site.
  • Flu-like symptoms are common after interferon injections, but are less likely with Interferon beta-1b in particular.
  • Blood testing required before and during use based on your other conditions.
  • Unclear consequences to fetus during pregnancy.
  • Some people have nausea and diarrhea when they start treatment. In most cases, these effects are mild and get better over time.
  • Aubagio can cause your hair to thin. This is temporary, and your hair will go back to normal after a few months.
  • You should have certain lab tests to make sure you don't have any problems from taking Aubagio. These include: complete blood count and liver enzyme testing within 6 months before you start treatment, tuberculosis (TB) screening, and blood pressure.
  • Numbness or tingling in your hands and feet (peripheral neuropathy), different from MS was reported more often than with sugar pill (placebo)
  • Aubagio may stay in your blood up to 2 years after you stop taking it. You can quickly remove Aubagio the accelerated elimination procedure, but symptoms of your disease may return.
  • You can't take it if you're pregnant.
Used for
Dosage forms
  • Injection
  • Pill
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Side effects
10possible side effects
  • Lymphocytes count decreased (<1500/mm3)
  • Asthenia
  • Immunogenicity
  • Headache
  • Flu-like symptoms (complex)
  • Pain
  • Hypertonia
  • Injection site reaction
  • Fever
  • Leukopenia
See more detailed side effects
1possible side effects
  • Moderate hypophospatemia
See more detailed side effects
Risks and warnings
  • Liver damage

    Alcohol use

    ...and 2 more risk factors

  • Suicidal thoughts or behavior

    History of depression or mental illness

  • Heart problems

    History of or current heart disease

  • Harm to fetus

    Women of childbearing age

  • Injection site reaction

    Not changing injection sites

  • Blood cell problems

    Bone marrow suppression

See more detailed risks and warnings
  • Liver problems

    Taking medicines that affect your liver or cause liver injury

  • Serious skin reactions

    Reaction to leflunomide

  • Numbness in extremities (hands and feet)

    Age 60 or older

    ...and 2 more risk factors

  • Serious Infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Kidney problems

    High uric acid levels

  • High potassium

    Acute kidney failure

  • Respiratory problems

    History of lung disease

  • High blood pressure

    History of high blood pressure

See more detailed risks and warnings