Compare Bisoprolol vs. Catapres

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zebeta (Bisoprolol)

Prescription only

Catapres (Clonidine)

Prescription only
Lowers blood pressure.

Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.

5.4/ 7 average rating with 18 reviewsforBisoprolol
Lowers blood pressure.

Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.

4.3/ 7 average rating with 78 reviewsforCatapres
  • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
  • Available in a generic version.
  • Also comes in combination with other medications to lower blood pressure.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
  • This isn't a first choice medication to lower blood pressure.
  • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Patch
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Side effects
The Zebeta (Bisoprolol) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Erythema / pruritis
  • Dry mouth
  • Drowsiness
  • Localized vesiculation
  • Fatigue
  • Headache
  • Allergic contact sensitization
  • Hyperpigmentation
  • Lethargy
  • Sedation
See more detailed side effects
Risks and warnings
  • Masked symptoms of low blood sugar


  • Heart attack

    Coronary artery disease

  • Increased symptoms of heart failure

    Heart failure

  • Increased risks during surgery

    Major surgery requiring anesthesia

See more detailed risks and warnings
  • Withdrawal

    Sudden discontinuation of medicine

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Low heart rate (bradycardia)

    Age 65 years or older

    ...and 1 more risk factors

See more detailed risks and warnings