Compare Bisoprolol vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(Hydrochlorothiazide )

Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
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Have you used Zebeta (Bisoprolol)?
Worth itNot sureNot worth it
Reviews for Microzide (Hydrochlorothiazide (Hctz))
-20% worse vs. Zebeta (Bisoprolol)
-30% worse vs. Zebeta (Bisoprolol)
+12% better vs. Zebeta (Bisoprolol)
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Pill
Used for
Risk factors for serious side effects
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    Detailed Zebeta (Bisoprolol) risks & warnings »
    • Current electrolyte imbalance
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
      Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Kidneys and liver
      No kidneys and liver related info.
      • Requires routine blood tests to check kidney function.
      Upsides and benefits
      • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
      • Available in a generic version.
      • Also comes in combination with other medications to lower blood pressure.
      • Works well to get rid of extra fluids in your body through urination.
      • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
      • Lowers the risk of heart attack and stroke.
      • Good option if you have both high blood pressure and heart failure.
      • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
      • Most people have very few side effects.
      Downsides and risks
      • This isn't a first choice medication to lower blood pressure.
      • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
      • Makes you urinate more often.
      • Doesn't work well in people with severe kidney problems.
      Tips from our pharmacists for people taking the medication
      • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
      • Don't stop taking it suddenly without talking to your doctor.
      • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
      • Can cause headache, fatigue, and make you more likely to get colds or the flu.
      • Starts working in about 2 hours.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
      • Requires routine blood tests to check kidney function.
      Learn more
      More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zebeta (Bisoprolol)?
      Worth itNot sureNot worth it
      More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Microzide (Hydrochlorothiazide (Hctz))?
      Worth itNot sureNot worth it