Compare Bisoprolol vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(hydrochlorothiazide )

Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Bisoprolol
of people (All ages) say Bisoprolol is worth it
say it works well
say it's a big hassle
Have you used Zebeta (bisoprolol)?
Worth itNot sureNot worth it
Reviews for hydrochlorothiazide
+20% better vs. Bisoprolol
+30% better vs. Bisoprolol
-12% worse vs. Bisoprolol
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Pill
Used for
Risk factors for serious side effects
  • Diabetes
  • Coronary artery disease
  • Heart failure
  • Major surgery requiring anesthesia
Detailed Zebeta (bisoprolol) risks & warnings »
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Kidneys and liver
No kidneys and liver related info.
  • Requires routine blood tests to check kidney function.
Upsides and benefits
  • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
  • Available in a generic version.
  • Also comes in combination with other medications to lower blood pressure.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides and risks
  • This isn't a first choice medication to lower blood pressure.
  • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Tips from our pharmacists for people taking the medication
  • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
  • Don't stop taking it suddenly without talking to your doctor.
  • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
  • Can cause headache, fatigue, and make you more likely to get colds or the flu.
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
Learn more
More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zebeta (bisoprolol)?
Worth itNot sureNot worth it
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it