Compare Boniva vs. Actonel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva
(ibandronate)

Actonel
(risedronate)

Prevents bone loss. Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss. Actonel (Risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle.
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Coupons for
Prices and coupon for 1 (3 tablets of 150mg) dose pack of ibandronate
Coupons for
Prices and coupon for 1 (1 tablet of 150mg) dose pack of risedronate
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.81Boniva
Reviews for Boniva (ibandronate)
31%
of people (All ages) say Boniva (ibandronate) is worth it
20%
say it works well
27%
say it's a big hassle
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it
Reviews for Actonel (risedronate)
36%
+5% better vs. Boniva (ibandronate)
19%
-1% worse vs. Boniva (ibandronate)
25%
+2% better vs. Boniva (ibandronate)
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
Side effects
BonivaActonel
  • Abdominal pain 8%
  • High blood pressure 6%
  • Joint pain 6%
  • Indigestion 6%
  • Diarrhea 5%
  • Back pain 5%
  • Nausea 5%
  • Constipation 4%
  • Cold 4%
  • Pain in arms or legs 4%
More Boniva side effects »

We haven’t found good data for Actonel side effects.

FDA side effect reports for Actonel »
How it works
BonivaActonel
Boniva (ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Actonel (Risedronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.
Type of medication
BonivaActonel
Prescription only
Prescription only
Available as
BonivaActonel
  • Pill
  • Injection
  • Pill
  • Extended release
Used for
BonivaActonel
Risk factors for serious side effects
BonivaActonel
  • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 60 minutes after taking the medicine
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Boniva (ibandronate)
      • History of low calcium in the blood
      Detailed Boniva (ibandronate) risks & warnings »
          • Oral or dental surgery
          • Cancer
          • Poor oral hygiene
              Detailed Actonel (risedronate) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Food
              BonivaActonel
              • Although rare, breakdown of the jawbone has happened in people taking Boniva (ibandronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. The risk might also increase the longer you take Boniva (ibandronate). If you notice pain or swelling in your jaw, talk to your doctor right away.
              • People on Actonel (Risedronate) have reported breakdown of the jaw bone. This is rare. This can happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain, swelling or an infection in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Actonel (Risedronate).
              Pain
              BonivaActonel
              • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
              • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
              Weight
              BonivaActonel
              No weight related info.
              • Consider adding weight-bearing exercises as part of your exercise routine.
              Upsides and benefits
              BonivaActonel
              • Available in generic.
              • Available in pills that can be taken by mouth once a month.
              • Also available as a shot given into your vein every 3 months.
              • Available in generic.
              • Available in oral tablets that can be taken once or twice a month, once a week, or once a day.
              Downsides and risks
              BonivaActonel
              • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
              • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
              • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
              • You have to take it first thing in the morning with a full glass of water.
              • You have to remain upright for at least 30 minutes after you take the medication, which can be a problem if you have mobility issues.
              Tips from our pharmacists for people taking the medication
              BonivaActonel
              • Can be taken as a pill or as an injection.
              • Take the pill first thing when you wake up by swallowing the whole pill with a full glass of plain water.
              • Don't eat or drink anything, or take other medicines for at least 60 minutes after you've taken the pill.
              • Stay sitting or standing for at least 60 minutes after you take the pill.
              • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
              • Take the 150 mg tablet on the same day every month. If you forget to take the 150 mg tablet on your chosen day each month, take it on the next day in the morning.
              • Keep taking your calcium and vitamin D.
              • If you're taking the fast release medication, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
              • Don't eat or drink anything for 30 minutes after you've taken the fast release medication.
              • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
              • Stay sitting or standing and Don't take any other medications, vitamins or supplements for at least 30 minutes after you take the medication.
              • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
              • Call your doctor if you develop pain in your jaw, hips or thighs.
              • Keep taking your calcium and vitamin D.
              • If you forget to take your dose, skip it and take it the following morning.
              • Some of these medications are only taken once or twice a month, others are taken once a week and others once a day. Talk to your pharmacist if you're not sure.
              • Consider adding weight-bearing exercises as part of your exercise routine.
              Learn more
              More about BonivaSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Boniva (ibandronate)?
              Worth itNot sureNot worth it
              More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Actonel (risedronate)?
              Worth itNot sureNot worth it