Compare Boniva vs. Actonel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva (ibandronate)

Prescription only

Actonel (risedronate)

Prescription only
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

3.8/ 7 average rating with 64 reviewsforBoniva
Prevents bone loss and fracture.

Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

3.8/ 7 average rating with 83 reviewsforActonel
Upsides
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Actonel (risedronate) is one of the first choice medicines used for the treatment and prevention of osteoporosis.
  • Available in a cheaper, generic form.
  • Can take tablet form once or twice a month, once a week, or once a day.
Downsides
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • Need to take Actonel (risedronate) on an empty stomach first thing in the morning with a full glass of water.
  • Requires the person taking this medicine to remain upright for at least 30 minutes after taking it, which can be a problem for those who have trouble sitting or standing.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Delayed-release pill
Price
Lowest price near you
$41.47
Find instant savings
Lowest price near you
$66.3
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
64 
31%
think this treatment is worth it
20%
think this treatment works well
27%
think this treatment is a hassle

Have you used Boniva (ibandronate)?

Leave a review
83 
36%
think this treatment is worth it
19%
think this treatment works well
25%
think this treatment is a hassle

Have you used Actonel (risedronate)?

Leave a review
Side effects
10possible side effects
  • Abdominal pain
    8%
  • High blood pressure
    6%
  • Indigestion
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Constipation
    4%
  • Pain in arms or legs
    4%
  • Flu
    4%
See more detailed side effects
10possible side effects
  • Infection
    31%
  • Back pain
    28%
  • Joint pain
    24%
  • Accidental injury
    17%
  • Generalized pain
    14%
  • Constipation
    13%
  • Stomach pain
    12%
  • Traumatic bone fracture
    12%
  • Flu-like symptoms
    11%
  • High blood pressure
    11%
See more detailed side effects
Risks and warnings
  • Irritation and ulcers to the stomach and esophagus

    Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)

    ...and 3 more risk factors

  • Problems in the jawbone

    Oral or dental surgery

    ...and 3 more risk factors

  • Low calcium in the blood

    History of low calcium in the blood

See more detailed risks and warnings
  • Irritation and ulcers in the stomach and esophagus

    History of ulcers, or other stomach or esophageal problems

    ...and 2 more risk factors

  • Problems in the jawbone

    Oral or dental surgery

    ...and 2 more risk factors

  • Low calcium in the blood

    History of low calcium in the blood

See more detailed risks and warnings