Compare Boniva vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva
(Ibandronate)

Evista
(Raloxifene)

Prevents bone loss. Boniva is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
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Reviews & ratings
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3.761904761904762Boniva
Reviews for Boniva (Ibandronate)
30%
of people (All ages) say Boniva (Ibandronate) is worth it
19%
say it works well
27%
say it's a big hassle
Have you used Boniva (Ibandronate)?
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Have you used Evista (Raloxifene)?
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Side effects
BonivaEvista
  • Any serious side effect 3%
More Boniva side effects »
  • Muscle spasms/leg cramps 4%
  • Leg cramps 3%
  • Sinus inflammation 3%
  • Leg or ankle swelling 2%
  • Muscle pain 2%
  • Sleep difficulty 2%
  • Rash 2%
  • Joint pain 2%
  • Weight gain 2%
  • Any side effect 1%
More Evista side effects »
How it works
BonivaEvista
Boniva (Ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
BonivaEvista
BisphosphonatePrescription only
Osteoporosis
Selective estrogen receptor modulator
Prescription only
Available as
BonivaEvista
  • Pill
  • Injection
  • Pill
Used for (click to learn more)
BonivaEvista
Risk factors for serious side effects
BonivaEvista
      • Oral or dental surgery
      • Cancer
      • Poor oral hygiene
          Detailed Boniva (Ibandronate) risks & warnings »
          • History of stroke
          • Heart and blood vessel problems
          • History of mini stroke (TIA)
          • Atrial fibrillation
          • Smoking
          • High blood pressure
            • History of high triglycerides
              Detailed Evista (Raloxifene) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

              Alcohol
              BonivaEvista
              No alcohol related info.
              • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
              Food
              BonivaEvista
              No food related info.
              • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
              Kidneys and liver
              BonivaEvista
              No kidneys and liver related info.
              • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
              Pain
              BonivaEvista
              • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
              No pain related info.
              Weight
              BonivaEvista
              • Consider adding weight-bearing exercises as part of your exercise routine.
              No weight related info.
              Upsides and benefits
              BonivaEvista
              • Available in generic.
              • Available in oral tablets that can be given once a month or once a day.
              • Also available as shot given into your vein every 3 months.
              • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
              • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
              • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
              Downsides and risks
              BonivaEvista
              • You have to take it first thing in the morning with a full glass of water.
              • You have to remain upright for at least 60 minutes after you take the medication, which can be a problem if you have mobility issues.
              • Only approved to treat and prevent osteoporosis in women who have gone through menopause.
              • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
              • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
              • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
              • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
              Tips from our pharmacists for people taking the medication
              BonivaEvista
              • Can be taken as a tablet or as an intravenous infusion.
              • Take the tablet first thing when you wake up by swallowing the whole pill with a full glass of plain water.
              • Don't eat or drink anything for 60 minutes after you've taken the tablet.
              • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
              • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
              • Take the 150 mg tablet on the same day every month.
              • If you forget to take the 150mg tablet on your chosen day each month, take it on the next day in the morning.
              • Call your doctor if you develop pain in your jaw, hips or thighs.
              • Keep taking your calcium and vitamin D.
              • Some of these medications are only taken once a month, others once a day. Talk to your pharmacist if you're not sure.
              • Consider adding weight-bearing exercises as part of your exercise routine.
              • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
              • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
              • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
              Learn more
              More about BonivaSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Boniva (Ibandronate)?
              Worth itNot sureNot worth it
              More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Evista (Raloxifene)?
              Worth itNot sureNot worth it