Compare Boniva vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva
(ibandronate)

Evista
(raloxifene)

Prevents bone loss. Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
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Coupons for Boniva
Best available price for 3 (3 tablets of 150mg) dose packs of boniva
Coupons for Evista
Best available price for 30 (60mg) tablets of evista
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.81Boniva
Reviews for Boniva
31%
of people (All ages) say Boniva is worth it
20%
say it works well
27%
say it's a big hassle
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it

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Have you used Evista (raloxifene)?
Worth itNot sureNot worth it
Side effects
BonivaEvista
  • Abdominal pain 8%
  • High blood pressure 6%
  • Joint pain 6%
  • Indigestion 6%
  • Diarrhea 5%
  • Back pain 5%
  • Nausea 5%
  • Constipation 4%
  • Cold 4%
  • Pain in arms or legs 4%
More Boniva side effects »
  • Joint pain 2%
  • Flu syndrome 3%
  • Any side effect 2%
  • Hot flashes 4%
  • Bronchitis 1%
More Evista side effects »
How it works
BonivaEvista
Boniva (ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
BonivaEvista
Prescription onlyPrescription only
Available as
BonivaEvista
  • Pill
  • Injection
  • Pill
Used for
BonivaEvista
Risk factors for serious side effects
BonivaEvista
  • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Oral or dental surgery
Detailed Boniva (ibandronate) risks & warnings »
  • History of stroke
  • Heart and blood vessel problems
  • History of mini stroke (TIA)
  • Atrial fibrillation
  • Smoking
Detailed Evista (raloxifene) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
BonivaEvista
No alcohol related info.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
Food
BonivaEvista
  • Although rare, breakdown of the jawbone has happened in people taking Boniva (ibandronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. The risk might also increase the longer you take Boniva (ibandronate). If you notice pain or swelling in your jaw, talk to your doctor right away.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
Kidneys and liver
BonivaEvista
No kidneys and liver related info.
  • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
Pain
BonivaEvista
  • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
No pain related info.
Upsides and benefits
BonivaEvista
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
Downsides and risks
BonivaEvista
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
Tips from our pharmacists for people taking the medication
BonivaEvista
  • Can be taken as a pill or as an injection.
  • Take the pill first thing when you wake up by swallowing the whole pill with a full glass of plain water.
  • Don't eat or drink anything, or take other medicines for at least 60 minutes after you've taken the pill.
  • Stay sitting or standing for at least 60 minutes after you take the pill.
  • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
  • Take the 150 mg tablet on the same day every month. If you forget to take the 150 mg tablet on your chosen day each month, take it on the next day in the morning.
  • Keep taking your calcium and vitamin D.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
  • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
Learn more
More about BonivaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it
More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Evista (raloxifene)?
Worth itNot sureNot worth it