Compare Boniva vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva (ibandronate)

Prescription only

Evista (Raloxifene)

Prescription only
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

3.8/ 7 average rating with 64 reviewsforBoniva
Prevents bone loss and lowers your risk of breast cancer.

Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.

  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
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Side effects
10possible side effects
  • Abdominal pain
  • High blood pressure
  • Indigestion
  • Joint pain
  • Nausea
  • Diarrhea
  • Back pain
  • Constipation
  • Pain in arms or legs
  • Flu
See more detailed side effects
6possible side effects
  • Any side effect
  • Peripheral edema
  • Muscle spasms/leg cramps
  • Hot Flashes
  • Cholelithiasis
  • Venous thromboembolic events
See more detailed side effects
Risks and warnings
  • Irritation and ulcers to the stomach and esophagus

    Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)

    ...and 3 more risk factors

  • Problems in the jawbone

    Oral or dental surgery

    ...and 3 more risk factors

  • Low calcium in the blood

    History of low calcium in the blood

See more detailed risks and warnings
  • Increased risk of stroke

    History of stroke

    ...and 5 more risk factors

  • Elevated triglycerides (fats in blood)

    History of high triglycerides

See more detailed risks and warnings