Compare Boniva vs. Reclast

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva (ibandronate)

Prescription only

Reclast (zoledronate)

Prescription only
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

2.9/ 5 average rating with 64 reviewsforBoniva
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

3.1/ 5 average rating with 39 reviewsforReclast
Upsides
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
Downsides
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
Used for
Dosage forms
  • Pill
  • Injection
  • Injection
Price
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Reviews
64 reviews so far
31%
saidit'sworth it
20%
saiditworked well
27%
saidit'sa big hassle

Have you used Boniva (ibandronate)?

Leave a review
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle

Have you used Reclast (zoledronate)?

Leave a review
Side effects
22possible side effects
  • Abdominal pain
    8%
  • High blood pressure
    6%
  • Indigestion
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Constipation
    4%
  • Pain in arms or legs
    4%
  • Flu
    4%
  • Cold
    4%
  • Localized joint stiffness and pain
    3%
  • Bronchitis
    3%
  • Headache
    3%
  • Influenza-like illness
    3%
  • Muscle pain
    2%
  • Muscle cramp
    2%
  • Urinary tract infection
    2%
  • Upper respiratory tract infection
    2%
  • Dizziness
    2%
  • Rash
    2%
  • Sleep difficulty
    2%
See more detailed side effects
17possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
  • Musculoskeletal stiffness
    5%
  • Lack of energy
    3%
  • Atrial fibrillation
    3%
  • Palpitations
    3%
  • Excessive sweating
    3%
  • Eye pain
    2%
  • Lower kidney function
    2%
See more detailed side effects
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
    • History of ulcers, or other stomach or esophageal problems
    • History of difficulty swallowing
    • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Pain in the bones and/or muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Boniva (ibandronate)
  • Leg bone fractures
  • Low calcium in the blood
    • History of low calcium in the blood
See more detailed risks and warnings
  • Pain in the bones and muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • Low parathyroid hormone
    • History of thyroid surgery
    • Problems with calcium absorption
  • Kidney injury
    • Kidney disease
    • Taking a water pill
    • Dehydrated
    • Elderly
See more detailed risks and warnings