Compare Boniva vs. Reclast

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva
(Ibandronate)

Reclast
(Zoledronate)

Prevents bone loss. Boniva is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss. Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.761904761904762Boniva
Reviews for Boniva (Ibandronate)
30%
of people say Boniva (Ibandronate) is worth it
19%
say it works well
27%
say it's a big hassle
Reviews for Reclast (Zoledronate)
25%
5% vs. Boniva (Ibandronate)
25%
+6% vs. Boniva (Ibandronate)
36%
9% vs. Boniva (Ibandronate)
Side effects
BonivaReclast
  • Any serious side effect 3%
More Boniva side effects »
  • Pain 20%
  • Fever 17%
  • Rash 16%
  • Chills 15%
  • Muscle pain 13%
  • Pain in jaw 12%
  • Fatigue 12%
  • Nausea 10%
  • Headache 9%
  • Joint pain 8%
More Reclast side effects »
How it works
BonivaReclast
Boniva (Ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Reclast (Zoledronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.
Type of medication
BonivaReclast
BisphosphonatePrescription only
BisphosphonatePrescription only
Available as
BonivaReclast
  • Pill
  • Injection
  • Injection
Used for (click to learn more)
BonivaReclast
Risk factors for serious side effects
BonivaReclast
      • Oral or dental surgery
      • Cancer
      • Poor oral hygiene
          Detailed Boniva (Ibandronate) risks & warnings »
            • Oral or dental surgery
            • Cancer
            • Poor oral hygiene
                Detailed Reclast (Zoledronate) risks & warnings »
                Pregnancy category
                BonivaReclast
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                DFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
                No specific food-related info.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                • Consider adding weight-bearing exercises as part of your exercise routine.
                No specific weight-related info.
                Upsides and benefits
                BonivaReclast
                • Available in oral tablets that can be given once a month or once a day.
                • Also available as shot given into your vein every 3 months.
                • Available in generic.
                • You only have to take this once a year.
                • Available in generic.
                Downsides and risks
                BonivaReclast
                • You have to take it first thing in the morning with a full glass of water.
                • You have to remain upright for at least 60 minutes after you take the medication, which can be a problem if you have mobility issues.
                • Only approved to treat and prevent osteoporosis in women who have gone through menopause.
                • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
                Tips from our pharmacists for people taking the medication
                BonivaReclast
                • Can be taken as a tablet or as an intravenous infusion.
                • Take the tablet first thing when you wake up by swallowing the whole pill with a full glass of plain water.
                • Don't eat or drink anything for 60 minutes after you've taken the tablet.
                • Stay sitting or standing, and Don't take any other medications, vitamins or supplements for at least 60 minutes after you take the tablet until you've had your first food of the day.
                • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
                • Take the 150 mg tablet on the same day every month.
                • If you forget to take the 150mg tablet on your chosen day each month, take it on the next day in the morning.
                • Call your doctor if you develop pain in your jaw, hips or thighs.
                • Keep taking your calcium and vitamin D.
                • Some of these medications are only taken once a month, others once a day. Talk to your pharmacist if you're not sure.
                • Consider adding weight-bearing exercises as part of your exercise routine.
                • Given as an intravenous infusion.
                • Eat normally and drink at least two glasses of liquid before your infusion.
                • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
                • Call your doctor if you develop pain in your hips, thighs or legs.
                • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
                • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
                • Drink plenty of liquids while you're on this medication.
                Learn more
                More about BonivaSide effectsReviews & ratingsAlternativesFDA package insert
                More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert