Compare Boniva vs. Reclast

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Boniva
(ibandronate)

Reclast
(zoledronate)

Prevents bone loss. Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss. Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.
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Coupons for Boniva
Best available price for 1 (3 tablets of 150mg) dose pack of boniva
Coupons for Reclast
Best available price for 1 (100ml of 5mg/100ml solution) bottle of reclast
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.81Boniva
Reviews for Boniva
31%
of people (All ages) say Boniva is worth it
20%
say it works well
27%
say it's a big hassle
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it
Reviews for Reclast
28%
+3% better vs. Boniva
28%
-8% worse vs. Boniva
36%
+9% better vs. Boniva
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
Side effects
BonivaReclast
  • Abdominal pain 8%
  • High blood pressure 6%
  • Joint pain 6%
  • Indigestion 6%
  • Diarrhea 5%
  • Back pain 5%
  • Nausea 5%
  • Constipation 4%
  • Cold 4%
  • Pain in arms or legs 4%
More Boniva side effects »
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Muscle aches 8%
  • Headache 4%
  • Pain in arms or legs 1%
  • Nausea 4%
  • Influenza-like illness 6%
  • Pain 20%
More Reclast side effects »
How it works
BonivaReclast
Boniva (ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Reclast (zoledronate) is a bisphosphonate. It slows down the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.
Type of medication
BonivaReclast
Prescription onlyPrescription only
Available as
BonivaReclast
  • Pill
  • Injection
  • Injection
Used for
BonivaReclast
Risk factors for serious side effects
BonivaReclast
  • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Oral or dental surgery
Detailed Boniva (ibandronate) risks & warnings »
  • Oral or dental surgery
  • Cancer
  • Poor oral hygiene
  • Low parathyroid hormone
  • History of thyroid surgery
Detailed Reclast (zoledronate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
BonivaReclast
  • Although rare, breakdown of the jawbone has happened in people taking Boniva (ibandronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. The risk might also increase the longer you take Boniva (ibandronate). If you notice pain or swelling in your jaw, talk to your doctor right away.
  • People on Reclast (zoledronate) have had breakdown of the jawbone. However, it is rare. It is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, before any oral/dental procedure, tell your surgeon that you are taking Reclast (zoledronate).
Kidneys and liver
BonivaReclast
No kidneys and liver related info.
  • It can't be used if you have really poor kidney function.
  • Reclast (zoledronate) can cause kidney injury, especially in people who already have problems with their kidneys. It is important that you get blood tests done before each dose to measure your kidney function. Reclast (zoledronate) shouldn’t be used in people who have very poor kidney function.
Pain
BonivaReclast
  • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
  • Joint pain and muscle pain are common side effects after the infusion.
Upsides and benefits
BonivaReclast
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
Downsides and risks
BonivaReclast
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
Tips from our pharmacists for people taking the medication
BonivaReclast
  • Can be taken as a pill or as an injection.
  • Take the pill first thing when you wake up by swallowing the whole pill with a full glass of plain water.
  • Don't eat or drink anything, or take other medicines for at least 60 minutes after you've taken the pill.
  • Stay sitting or standing for at least 60 minutes after you take the pill.
  • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
  • Take the 150 mg tablet on the same day every month. If you forget to take the 150 mg tablet on your chosen day each month, take it on the next day in the morning.
  • Keep taking your calcium and vitamin D.
  • Eat normally and drink at least 2 glasses of liquid before your infusion.
  • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
  • Talk to your doctor if you develop swelling, pain, or soreness in your jaw.
  • Call your doctor if you develop pain in your hips, thighs, or legs.
  • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
  • Drink plenty of liquids while you're on this medicine.
Learn more
More about BonivaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it
More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it