Compare Buspar vs. Lexapro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Buspar
(buspirone)

Lexapro
(escitalopram)

Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.
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Prices and coupon for 60 (10mg) tablets of buspirone
Coupons for
Prices and coupon for 30 (10mg) tablets of escitalopram
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.63Buspar
Reviews for Buspar (buspirone)
46%
of people (All ages) say Buspar (buspirone) is worth it
45%
say it works well
22%
say it's a big hassle
Have you used Buspar (buspirone)?
Worth itNot sureNot worth it
Reviews for Lexapro (escitalopram)
61%
+15% better vs. Buspar (buspirone)
48%
+3% better vs. Buspar (buspirone)
15%
+7% better vs. Buspar (buspirone)
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
Side effects
BusparLexapro
  • Dizziness 9%
  • Any side effect 10%
  • Drowsiness 1%
  • Nausea 3%
  • Headache 3%
  • Nervousness 4%
  • Central nervous system disturbances 3%
More Buspar side effects »
  • Nausea 8%
  • Sleep difficulty 5%
  • Problems with ejaculation 9%
  • Diarrhea 3%
  • Dry mouth 1%
  • Drowsiness 4%
  • Runny nose 1%
  • Fatigue 3%
  • Dizziness 2%
  • Flu-like symptoms 1%
More Lexapro side effects »
How it works
BusparLexapro
Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.
Type of medication
BusparLexapro
Prescription only
Prescription only
Available as
BusparLexapro
  • Pill
  • Pill
  • Liquid
Used for
BusparLexapro
Risk factors for serious side effects
BusparLexapro
  • Taking with MAOIs
  • Taking with Zyvox or methylene blue
  • Taking with or converting from benzodiazepine medicines
  • Duration of treatment
Detailed Buspar (buspirone) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (escitalopram) suddenly
  • Taking blood thinners
    • Bipolar disorder
    Detailed Lexapro (escitalopram) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    BusparLexapro
    No interactions related info.
    • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
    Alcohol
    BusparLexapro
    • Avoid alcohol when taking Buspar (Buspirone).
    No alcohol related info.
    Food
    BusparLexapro
    • Be consistent in taking Buspar (Buspirone) with or without food.
    No food related info.
    Sleep
    BusparLexapro
    • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
    No sleep related info.
    Weight
    BusparLexapro
    No weight related info.
    • Can cause a small weight gain of 1-5 pounds.
    Upsides and benefits
    BusparLexapro
    • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
    • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
    • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
    • Effective at relieving depression and anxiety symptoms.
    • Lowers the likelihood that your depression will come back.
    • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
    Downsides and risks
    BusparLexapro
    • Buspar (Buspirone) can take as long as four weeks to become fully effective.
    • Not as effective for short-term anxiety conditions or panic disorders.
    • Most people find that it loses effectiveness over long periods of time.
    • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
    • Can cause a small weight gain of 1-5 pounds.
    • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
    • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    BusparLexapro
    • Take doses at about the same time each day.
    • It can take several weeks to get the full effect.
    • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
    • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
    • Be consistent in taking Buspar (Buspirone) with or without food.
    • Avoid alcohol when taking Buspar (Buspirone).
    • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
    • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
    Learn more
    More about BusparSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Buspar (buspirone)?
    Worth itNot sureNot worth it
    More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lexapro (escitalopram)?
    Worth itNot sureNot worth it