Compare Buspar vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Buspar
(buspirone)

Oleptro
(trazodone)

Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Coupons for Buspar
Best available price for 60 (10mg) tablets of buspar
Coupons for Oleptro
Best available price for 30 (50mg) tablets of trazodone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.63Buspar
Reviews for Buspar
46%
of people (All ages) say Buspar is worth it
45%
say it works well
22%
say it's a big hassle
Have you used Buspar (buspirone)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-27% worse vs. Buspar
49%
-4% worse vs. Buspar
24%
+2% better vs. Buspar
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
BusparOleptro
  • Dizziness 9%
  • Any side effect 10%
  • Drowsiness 1%
  • Nausea 3%
  • Headache 3%
  • Nervousness 4%
  • Central nervous system disturbances 3%
More Buspar side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
BusparOleptro
Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
BusparOleptro
Prescription onlyPrescription only
Available as
BusparOleptro
  • Pill
  • Pill
  • Extended release
Used for
BusparOleptro
Risk factors for serious side effects
BusparOleptro
  • Taking with MAOIs
  • Taking with Zyvox or methylene blue
  • Taking with or converting from benzodiazepine medicines
  • Duration of treatment
Detailed Buspar (buspirone) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
BusparOleptro
  • Avoid alcohol when taking Buspar (Buspirone).
No alcohol related info.
Food
BusparOleptro
  • Be consistent in taking Buspar (Buspirone) with or without food.
No food related info.
Sleep
BusparOleptro
  • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
No sleep related info.
Upsides and benefits
BusparOleptro
  • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
  • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
  • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
BusparOleptro
  • Buspar (Buspirone) can take as long as four weeks to become fully effective.
  • Not as effective for short-term anxiety conditions or panic disorders.
  • Most people find that it loses effectiveness over long periods of time.
  • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
BusparOleptro
  • Take doses at about the same time each day.
  • It can take several weeks to get the full effect.
  • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
  • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
  • Be consistent in taking Buspar (Buspirone) with or without food.
  • Avoid alcohol when taking Buspar (Buspirone).
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about BusparSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Buspar (buspirone)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it