Compare Buspar vs. Prozac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Buspar (Buspirone)

Prescription only

Prozac (fluoxetine)

Prescription only
Helps you relax.

Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.

3.4/ 5 average rating with 67 reviewsforBuspar
Improves mood and helps you relax.

Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

3.5/ 5 average rating with 1319 reviewsforProzac
Upsides
  • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
  • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
  • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
  • Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • Might be a good option for treating children with depression and/or OCD.
  • Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
Downsides
  • Buspar (Buspirone) can take as long as four weeks to become fully effective.
  • Not as effective for short-term anxiety conditions or panic disorders.
  • Most people find that it loses effectiveness over long periods of time.
  • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
  • Can lower your sex drive.
  • Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
  • You may need to try out several different antidepressants before you find the one that works for you.
Used for
Dosage forms
  • Pill
  • Pill
  • Delayed-release pill
  • Liquid
Price
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Reviews
67 reviews so far
46%
saidit'sworth it
45%
saiditworked well
22%
saidit'sa big hassle

Have you used Buspar (Buspirone)?

Leave a review
1319 reviews so far
62%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Prozac (fluoxetine)?

Leave a review
Side effects
21possible side effects
  • Dizziness
    12%
  • Any side effect
    10%
  • Drowsiness
    10%
  • Nausea
    8%
  • Headache
    6%
  • Nervousness
    5%
  • Fatigue
    4%
  • Central nervous system disturbances
    3%
  • Insomnia
    3%
  • Lightheadedness
    3%
  • Dry Mouth
    3%
  • Decreased Concentration
    2%
  • Excitement
    2%
  • Anger/Hostility
    2%
  • Confusion
    2%
  • Depression
    2%
  • Blurred Vision
    2%
  • Abdominal/Gastric Distress
    2%
  • Diarrhea
    2%
  • Numbness
    2%
  • Weakness
    2%
See more detailed side effects
22possible side effects
  • Inability to sleep
    33%
  • Nausea
    28%
  • Lack of energy
    21%
  • Anxiety
    15%
  • Sleepiness
    13%
  • Tremor
    13%
  • Nervousness
    11%
  • Yawn
    11%
  • Indigestion
    10%
  • Sore throat
    10%
  • Dry mouth
    9%
  • Flu syndrome
    8%
  • Diarrhea
    8%
  • Loss of appetite
    8%
  • Sweating
    8%
  • Impotence
    7%
  • Abnormal ejaculation
    7%
  • Sinus infection
    6%
  • Lower sex drive
    5%
  • Abnormal dreams
    5%
  • Rash
    4%
  • Widening of blood vessels
    2%
See more detailed side effects
Risks and risk factors
  • Elevated blood pressure
    • Taking with MAOIs
    • Taking with Zyvox or methylene blue
  • Withdrawal reactions
    • Taking with or converting from benzodiazepine medicines
  • Abnormal and involuntary muscle movements
    • Duration of treatment
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Antidepressants
    • Lithium
    • Ultram
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
    • St. John's Wort
  • Skin rash
  • Weight loss
    • People with an eating disorder
  • Increased bleeding risk
    • Taking NSAIDS or blood-thinning drugs
  • Abnormal heart rhythm
    • People with heart rhythm problems or a family history of them
    • Low potassium level
    • Low magnesium level
    • Recent heart attack
    • Using other drugs that affect heart rhythm
    • Overdose
    • People with liver problems
See more detailed risks and warnings