Compare Buspar vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Buspar
(Buspirone)

Remeron
(Mirtazapine)

Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.63Buspar
Reviews for Buspar (Buspirone)
46%
of people (All ages) say Buspar (Buspirone) is worth it
45%
say it works well
22%
say it's a big hassle
Have you used Buspar (Buspirone)?
Worth itNot sureNot worth it
Reviews for Remeron (Mirtazapine)
45%
-1% worse vs. Buspar (Buspirone)
39%
-6% worse vs. Buspar (Buspirone)
26%
-4% worse vs. Buspar (Buspirone)
152 reviews
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it
Side effects
BusparRemeron
  • Dizziness 9%
  • Any side effect 10%
  • Drowsiness 1%
  • Nausea 3%
  • Headache 3%
  • Nervousness 4%
  • Central nervous system disturbances 3%
More Buspar side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
BusparRemeron
Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
BusparRemeron
Prescription only
Prescription only
Available as
BusparRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for
BusparRemeron
Risk factors for serious side effects
BusparRemeron
  • Taking with MAOIs
  • Taking with Zyvox or methylene blue
  • Taking with or converting from benzodiazepine medicines
  • Duration of treatment
Detailed Buspar (Buspirone) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
  • Alcohol
  • Taking other medicines that make you less alert
      Detailed Remeron (Mirtazapine) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      BusparRemeron
      • Avoid alcohol when taking Buspar (Buspirone).
      No alcohol related info.
      Food
      BusparRemeron
      • Be consistent in taking Buspar (Buspirone) with or without food.
      No food related info.
      Sleep
      BusparRemeron
      • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
      No sleep related info.
      Weight
      BusparRemeron
      No weight related info.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Can increase appetite and weight.
      • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
      Upsides and benefits
      BusparRemeron
      • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
      • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
      • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
      • Effective at relieving some depression symptoms.
      • Starts to work more quickly than most antidepressants.
      • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
      • Good option for people who are underweight or frail, because it can help you gain weight.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      BusparRemeron
      • Buspar (Buspirone) can take as long as four weeks to become fully effective.
      • Not as effective for short-term anxiety conditions or panic disorders.
      • Most people find that it loses effectiveness over long periods of time.
      • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      BusparRemeron
      • Take doses at about the same time each day.
      • It can take several weeks to get the full effect.
      • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
      • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
      • Be consistent in taking Buspar (Buspirone) with or without food.
      • Avoid alcohol when taking Buspar (Buspirone).
      • Makes you sleepy. Take at bedtime.
      • Can increase appetite and weight.
      • Takes 8 to 12 weeks to see full effects on mood.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about BusparSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Buspar (Buspirone)?
      Worth itNot sureNot worth it
      More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Remeron (Mirtazapine)?
      Worth itNot sureNot worth it