Compare Byetta vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Byetta
(Exenatide)

Glyburide / Metformin
()

Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.
Reviews & ratings
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Have you used Byetta (Exenatide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Side effects
ByettaGlucovance
  • Low blood sugar 11%
  • Gas 1%
  • Gastroesophageal reflux disease (GERD) 1%
  • Loss of appetite 3%
  • Abdominal swelling 3%
  • Weakness 4%
  • Indigestion 5%
  • Constipation 8%
  • Headache 10%
  • Vomiting 14%
More Byetta side effects »
  • Dizziness 2%
  • Stomach pain 3%
  • Nausea/vomiting 2%
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Low blood sugar 8%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
More Glucovance side effects »
How it works
ByettaGlucovance
Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.
Type of medication
ByettaGlucovance
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
ByettaGlucovance
  • Injection
  • Pill
Used for
ByettaGlucovance
Risk factors for serious side effects
ByettaGlucovance
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (Exenatide) risks & warnings »
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ByettaGlucovance
No alcohol related info.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
Kidneys and liver
ByettaGlucovance
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
  • Not a good treatment option for those with kidney and/or liver problems.
Pain
ByettaGlucovance
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
No pain related info.
Weight
ByettaGlucovance
No weight related info.
  • Can cause some weight gain.
Upsides and benefits
ByettaGlucovance
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides and risks
ByettaGlucovance
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Tips from our pharmacists for people taking the medication
ByettaGlucovance
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
  • Check your blood sugar regularly.
  • Wear sunscreen and appropriate clothing to protect yourself from the sun.
  • Take the medicine with meals to prevent an upset stomach.
  • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
Learn more
More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Byetta (Exenatide)?
Worth itNot sureNot worth it
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glyburide / Metformin?
Worth itNot sureNot worth it