Compare Byetta vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Byetta
(Exenatide)

Glucovance
(Metformin / Glyburide)

Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
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Side effects
ByettaGlucovance
  • Low blood sugar 33%
  • Nausea 26%
  • Vomiting 14%
  • Headache 10%
  • Diarrhea 10%
  • Constipation 8%
  • Indigestion 6%
  • Feeling jittery 5%
  • Muscle weakness 4%
  • Dizziness 3%
More Byetta side effects »
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »
How it works
ByettaGlucovance
Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
ByettaGlucovance
Anti-diabetic
Incretin mimetic
Prescription only
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Available as
ByettaGlucovance
  • Injection
  • Pill
Used for (click to learn more)
ByettaGlucovance
Risk factors for serious side effects
ByettaGlucovance
        • Severe renal impairment
        • End-stage renal disease
        • Severe gastrointestinal disease
        • Gastroparesis
          Detailed Byetta (Exenatide) risks & warnings »
          • Kidney problems
          • Liver problems
          • Congestive heart failure
          • Using contrast dye for procedures
          • Surgery
          • Alcohol use
            • Elderly
            • Use of other blood sugar lowering medicines
            • Alcohol use
            • Intense physical activity
            • History of sulfa reactions
              Detailed Glucovance (Metformin / Glyburide) risks & warnings »
              Pregnancy category
              ByettaGlucovance
              Alcohol
              No specific alcohol-related info.
              • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
              • Try limiting the amount of alcohol you drink while taking this medication.
              Food
              • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
              • Eat regular, balanced meals to avoid low blood sugar.
              • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
              Kidneys and liver
              • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
              • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
              • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
              • Can cause some weight gain.
              Upsides and benefits
              ByettaGlucovance
              • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
              • Prevents the harmful effects of high sugar levels on your organs.
              • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
              • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
              • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
              • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
              • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
              • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
              • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
              • Also lowers certain lipid (fat and cholesterol) levels.
              Downsides and risks
              ByettaGlucovance
              • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
              • Byetta (Exenatide) must be injected twice a day.
              • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
              • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
              • Other diabetes medications work as well and are cheaper.
              • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
              • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
              • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
              • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
              • Can cause some weight gain.
              Tips from our pharmacists for people taking the medication
              ByettaGlucovance
              • Store in the refrigerator until opening. Do not freeze.
              • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
              • Change the needle and prime the pen every time you inject.
              • It’s not safe to share this medication with other people, even if you change the needle.
              • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
              • Eat regular, balanced meals to avoid low blood sugar.
              • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
              • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
              • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
              • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
              • Try limiting the amount of alcohol you drink while taking this medication.
              • Check your blood sugar regularly.
              Learn more
              More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
              More about GlucovanceSide effectsAlternativesFDA package insert