Compare Byetta vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Byetta (Exenatide)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Upsides
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Injection
  • Pill
Price
Lowest price near you
$644.4
Find instant savings
Lowest price near you
$10
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
Side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Kidney problems

    Severe renal impairment

    ...and 1 more risk factors

  • Serious stomach problems

    Severe gastrointestinal disease

    ...and 1 more risk factors

See more detailed risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings